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Rat Anti-Mouse Interleukin-6 (IL-6) ELISA Set

BACKGROUND
Interleukin 6 (IL-6) is a 22-28kD α-helical protein that is secreted by a variety of cells including monocytes, fibroblasts, B and T cells, endothelial cells and glial cells[1]. This cytokine signals through a receptor complex consisting of the IL-6 receptor subunit and the ubiquitously expressed signal transducing subunit gp130 [2]. On target cells, IL-6 binding induces gp130 recruitment and subsequent activation of the MAPK and Jak/Stat signaling pathways. IL-6 stimulates B cells into antibody secreting cells and acts as a growth factor for numerous cell types including hematopoietic precursor cells, T cells, neuronal cells and hybridoma cells[3-5]. IL-6 has also been linked to thymocyte development and the induction of acute phase response in hepatocytes,[6,7].
[Technical Bulletin / References ] Back to Immunoassay Sets - Mouse Cytokines
 Cat. No.Product DescriptionCloneSize
USD Price
Order Qty
14300-01
 
Anti-Mouse IL-6 ELISA Set
Set
$350.00
FORMAT ABBREVIATIONS:
UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
 CY3 - CyanineTM 3-labeled *
SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.