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Rat Anti-Mouse GM-CSF ELISA Set

BACKGROUND
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is a hematopoietic cytokine secreted by a variety of cells including macrophages, T cells, endothelial cells and fibroblasts[1]. GM-CSF receptors are found on several cell types such as monocytes, macrophages and granulocytes and upon binding induce signaling through the Jak/Stat and MAPK pathways[2]. It promotes inflammation and host defense by stimulating differentiation of granulocytes, macrophages and dendritic cells from hematopoietic progenitor cells and increasing mature effector cell function[3-5]. Recently, it has also been shown to promote neuronal growth in the brain to counteract apoptosis and reduce infarct size in stroke models in vivo[6,7]. Clinically, GMCSF is used to ameliorate the symptoms of chemotherapy-induced neutropenia and monocytopenia by promoting the release of progenitor cells from bone marrow[8,9].
[Technical Bulletin / References ] Back to Immunoassay Sets - Mouse Cytokines
 Cat. No.Product DescriptionCloneSize
USD Price
Order Qty
14400-01
 
Anti-Mouse GM-CSF ELISA Set
$350.00
FORMAT ABBREVIATIONS:
UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
 CY3 - CyanineTM 3-labeled *
SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.