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Rat Anti-Mouse CD49d (VLA-4α, Integrin α4)

ANTIGEN DESCRIPTION
VLA-4 belongs to the β1-integrin family, which functions both as cell-matrix and cell-cell receptors.[1-3] As a matrix receptor VLA-4 binds to an alternatively spliced domain of fibronectin, while as a cellular receptor it associates with its counter-receptor ligand VCAM-1.[1,2] In addition to CD44/pgp-1, VLA-4 has been shown to be important for lymphopoiesis, and is also believed to be important for extravasation of lymphocytes into sites of inflammation as a second signal in addition to LFA/ICAM-1.[2,3] CD49d/VLA-4 is expressed in low amounts on resting lymphocytes and monocytes, is absent or minimally detectable on stromal cells, whereas virtually all lymphoid and myeloid cells in bone marrow and in long-term culture are positive.[1,2] Antibody PS/2 also reacts with human VLA-4.[1]
[Technical Bulletin / References ] Back to CD Markers and Other Cell Surface Proteins - Specificity Mouse
 Cat. No.Product DescriptionCloneSize
USD Price
Order Qty
1520-01
 
Rat Anti-Mouse CD49d/VLA-4a-UNLB
PS/2 0.5 mg
$192.00
1520-02
 
Rat Anti-Mouse CD49d/VLA-4a-FITC
PS/2 0.5 mg
$245.00
1520-08
 
Rat Anti-Mouse CD49d/VLA-4a-BIOT
PS/2 0.5 mg
$222.00
1520-09
 
Rat Anti-Mouse CD49d/VLA-4a-R-PE
PS/2 0.1 mg
$190.00
1520-09L
 
Rat Anti-Mouse CD49d/VLA-4a-R-PE
PS/2 0.2 mg
$245.00
1520-14
 
Rat Anti-Mouse CD49d/VLA-4a-LE/AF
PS/2 0.5 mg
$225.00
FORMAT ABBREVIATIONS:
UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
 CY3 - CyanineTM 3-labeled *
SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.