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Rat Anti-Mouse CD4 (L3T4)

ANTIGEN DESCRIPTION
CD4/L3T4 is a type I transmembrane glycoprotein expressed on most thymocytes and the helper/inducer subpopulation of mature T lymphocytes of all mouse strains tested.[1,2] CD4 has also been detected at low density on pluripotent hematopoietic stem cells, bone marrow myeloid precursors, and intrathymic lymphoid precursors.[3-6] The CD4 antigen functions as a co-receptor, interacting with class II major histocompatability complex (MHC) molecules in the recognition of foreign antigens by T cells.[1,2] In vivo and in vitro treatment with the GK1.[5] mAb effectively depletes CD4+ cells.[7,8] The mAb also blocks helper T cell responses to MHC class II antigens, including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines.[1,8-13]
[Technical Bulletin / References ] Back to CD Markers and Other Cell Surface Proteins - Specificity Mouse
 Cat. No.Product DescriptionCloneSize
USD Price
Order Qty
1540-01
 
Rat Anti-Mouse CD4/L3T4-UNLB
GK1.5 0.5 mg
$158.00
1540-02
 
Rat Anti-Mouse CD4/L3T4-FITC
GK1.5 0.5 mg
$212.00
1540-02S
 
Rat Anti-Mouse CD4/L3T4-FITC
GK1.5 0.1 mg
$80.00
1540-08
 
Rat Anti-Mouse CD4/L3T4-BIOT
GK1.5 0.5 mg
$192.00
1540-09
 
Rat Anti-Mouse CD4/L3T4-R-PE
GK1.5 0.1 mg
$95.00
1540-09L
 
Rat Anti-Mouse CD4/L3T4-R-PE
GK1.5 0.2 mg
$142.00
1540-10
 
Rat Anti-Mouse CD4/L3T4-UNLB
GK1.5 0.1 mg
$205.00
1540-11
 
Rat Anti-Mouse CD4/L3T4-APC
GK1.5 0.1 mg
$222.00
1540-13
 
Rat Anti-Mouse CD4/L3T4-SPRD
GK1.5 0.1 mg
$197.00
1540-14
 
Rat Anti-Mouse CD4/L3T4-LE/AF
GK1.5 0.5 mg
$192.00
1540-15
 
Rat Anti-Mouse CD4/L3T4-CY5
GK1.5 0.1 mg
$245.00
1540-16
 
Rat Anti-Mouse CD4/L3T4-PE/CY5.5
GK1.5 0.1 mg
$235.00
1540-17
 
Rat Anti-Mouse CD4/L3T4-PE/CY7
GK1.5 0.1 mg
$192.00
1540-18
 
Rat Anti-Mouse CD4/L3T4-APC/CY5.5
GK1.5 0.1 mg
$205.00
1540-19
 
Rat Anti-Mouse CD4/L3T4-APC/Cy7
GK1.5 0.1 mg
$192.00
1540-30
 
Rat Anti-Mouse CD4/L3T4-Alexa Fluor 488
GK1.5 0.1 mg
$192.00
1540-31
 
Rat Anti-Mouse CD4/L3T4-Alexa Fluor 647
GK1.5 0.1 mg
$192.00
FORMAT ABBREVIATIONS:
UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
 CY3 - CyanineTM 3-labeled *
SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.