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Rat Anti-Mouse CD5 (Ly-1)

ANTIGEN DESCRIPTION
CD5/Lyt-1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells.[1-3] It has been identified as the major ligand of the B-cell antigen CD72.[4,5] The frequency of CD5+ B cells exhibits strain-dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B-1 cells reviewed in 6. Binding of CD5 on the T cell surface can augment alloantigen- or mitogen-induced lymphocyte proliferation and induces increased cytosolic free calcium, IL-2 secretion, and IL-2R expression.[7-12] It has been proposed that CD5 negatively regulates signal transduction mediated by the T-cell and B-cell receptors.[13, 14]
[Technical Bulletin / References ] Back to CD Markers and Other Cell Surface Proteins Product List
 Cat. No.Product DescriptionCloneSize
USD Price
Order Qty
1546-01
 
Rat Anti-Mouse CD5/Ly-1-UNLB
4H8E6 0.5 mg
$190.00
1546-02
 
Rat Anti-Mouse CD5/Ly-1-FITC
4H8E6 0.5 mg
$250.00
1546-02S
 
Rat Anti-Mouse CD5/Ly-1-FITC
4H8E6 0.1 mg
$90.00
1546-08
 
Rat Anti-Mouse CD5/Ly-1-BIOT
4H8E6 0.5 mg
$250.00
1546-09
 
Rat Anti-Mouse CD5/Ly-1-R-PE
4H8E6 0.1 mg
$160.00
1546-09L
 
Rat Anti-Mouse CD5/Ly-1-R-PE
4H8E6 0.2 mg
$260.00
1546-11
 
Rat Anti-Mouse CD5/Ly-1-APC
4H8E6 0.1 mg
$305.00
1546-13
 
Rat Anti-Mouse CD5/Ly-1-SPRD
4H8E6 0.1 mg
$255.00
FORMAT ABBREVIATIONS:
UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
 CY3 - CyanineTM 3-labeled *
SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.