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Rat Anti-Mouse CD11b (Mac-1α, Intergrin αM)

ANTIGEN DESCRIPTION
CD11b, the integrin αM subunit, combines with CD18, the integrin β2 subunit, to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1/CD54.[2, 3] Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities.[2-8] Mac-1 expression is rapidly up-regulated on neutrophils after activation and in the same time period that CD62L is shed from the cell surface. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils.[4,9,10] Cross-reaction of M1/70 to human CD11b has been observed on monocytes, polymorphonuclear leukocytes, and NK cells.[4,8]
[Technical Bulletin / References ] Back to CD Markers and Other Cell Surface Proteins - Specificity Mouse
 Cat. No.Product DescriptionCloneSize
USD Price
Order Qty
1561-01
 
Rat Anti-Mouse CD11b/Mac-1a-UNLB
M1/70 0.5 mg
$162.00
1561-02
 
Rat Anti-Mouse CD11b/Mac-1a-FITC
M1/70 0.5 mg
$245.00
1561-02S
 
Rat Anti-Mouse CD11b/Mac-1a-FITC
M1/70 0.1 mg
$115.00
1561-08
 
Rat Anti-Mouse CD11b/Mac-1a-BIOT
M1/70 0.5 mg
$222.00
1561-09
 
Rat Anti-Mouse CD11b/Mac-1a-R-PE
M1/70 0.1 mg
$140.00
1561-09L
 
Rat Anti-Mouse CD11b/Mac-1a-R-PE
M1/70 0.2 mg
$245.00
1561-11
 
Rat Anti-Mouse CD11b/Mac-1a-APC
M1/70 0.1 mg
$196.00
1561-13
 
Rat Anti-Mouse CD11b/Mac-1a-SPRD
M1/70 0.1 mg
$196.00
1561-14
 
Rat Anti-Mouse CD11b/Mac-1a-LE/AF
M1/70 0.5 mg
$235.00
1561-15
 
Rat Anti-Mouse CD11b/Mac-1a-CY5
M1/70 0.1 mg
$250.00
1561-17
 
Rat Anti-Mouse CD11b/Mac-1a-PE/CY7
M1/70 0.1 mg
$192.00
1561-19
 
Rat Anti-Mouse CD11b/Mac-1a-APC/CY7
M1/70 0.1 mg
$222.00
FORMAT ABBREVIATIONS:
UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
 CY3 - CyanineTM 3-labeled *
SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.