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Mouse anti-Human Interleukin-33 (IL-33)

ANTIGEN DESCRIPTION
Interleukin-33 (IL-33), also known as NF-HEV, is a 30kD protein and a recently identified member of the IL-1 family. This pro-inflammatory cytokine is produced by a variety of cells, but is primarily expressed by endothelial and smooth muscle cells in the vasculature and airways[2]. IL-33 binds to the ST2 receptor on target cells which results in the activation of multiple signaling pathways including NF-κB and MAP kinases. Studies have shown that IL-33 promotes T helper type 2 (Th2) cell-mediated immune responses and upregulates production of Th2 associated cytokines including IL-4, IL-5 and IL-13[3,4]. In vivo administration of this cytokine in mice resulted in eosinophilia and splenomegaly, as well as induced severe pathological changes in the lungs, gastrointestinal tract and other mucosal organs[3,5,6].
[Technical Bulletin / References ] Back to Cytokine Research - Human
 Cat. No.Product DescriptionCloneSize
USD Price
Order Qty
15710-01
 
Mouse Anti-Human IL-33-UNLB
SB127J 0.5 mg
$270.00
15710-08
 
Mouse Anti-Human IL-33-BIOT
SB127J 0.5 mg
$335.00
FORMAT ABBREVIATIONS:
UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
 CY3 - CyanineTM 3-labeled *
SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.