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 Rat Anti-Mouse CD25 (IL-2Rα)

ANTIGEN DESCRIPTION
The IL-2 receptor (IL-2R) exists in three alternative forms made up from the individual components of CD25, CD122, and CD132. CD25 represents the low affinity α chain of the IL-2R, a type I transmembrane glycoprotein containing two CCP domains. It is rich in O-linked carbohydrates and has a short cytoplasmic tail.[2] CD25 is expressed on activated T cells, B cells, NK cells and monocytes of all mouse strains tested.[1,3,4] It is transiently expressed at a low level during B-cell development in bone marrow on the CD45R/B220 low TdT- sIg- pre-B II and CD45R/B220low TdT- sIgM+sIgD- immature B cells, but not on the CD45R/B220 low TdT+ sIg- pro-B/pre-B I stage nor on CD45R/B220 high TdT- sIgM+sIgD+ mature B cells.[5,6] CD25 is expressed at a higher level during very early T-cell development in fetal and adult thymus.[6, 7] The 7D4 monoclonal antibody reacts with an epitope between amino acids 125 and 212 that is distinct from that recognized by the monoclonal antibody 3C7 (Cat. No. 1600-XX). While the monoclonal antibody 7D4 does not block the binding of IL-2 to CD25, when used in combination with the monoclonal antobody 3C7 it results in higher levels of inhibition of IL-2-driven proliferation than either of these two monoclonal antibodies alone.[3,8,9]
[Technical Bulletin / References ] Back to CD Markers and Other Cell Surface Proteins Product List
  Cat.no.
  Product Description Format Size
USD Price   Order Qty  
1595-01
  		  Rat Anti-Mouse CD25/IL-2Ra-UNLB $245.00
  Clone:7D4 UNLB 0.5 mg
1595-02
  		  Rat Anti-Mouse CD25/IL-2Ra-FITC $320.00
  Clone:7D4 FITC 0.5 mg
1595-02S
  		  Rat Anti-Mouse CD25/IL-2Ra-FITC $110.00
  Clone:7D4 FITC 0.1 mg
1595-08
  		  Rat Anti-Mouse CD25/IL-2Ra-BIOT $300.00
  Clone:7D4 BIOT 0.5 mg
1595-09
  		  Rat Anti-Mouse CD25/IL-2Ra-PE $215.00
  Clone:7D4 R-PE 0.1 mg
1595-09L
  		  Rat Anti-Mouse CD25/IL-2Ra-PE $345.00
  Clone:7D4 R-PE 0.2 mg
1595-11
  		  Rat Anti-Mouse CD25/IL-2Ra-APC $225.00
  Clone:7D4 APC 0.1 mg
1595-13
  		  Rat Anti-Mouse CD25/IL-2Ra-SPRD $220.00
  Clone:7D4 SPRD 0.1 mg
1595-14
  		  Rat Anti-Mouse CD25/IL-2Ra-LE/AF $305.00
  Clone:7D4 LE/AF 0.5 mg
1595-17
  		  Rat Anti-Mouse CD25/IL-2Ra-PE/CY7 $210.00
  Clone:7D4 PE/CY7 0.1 mg
FORMAT ABBREVIATIONS:
UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
CY3 - CyanineTM 3-labeled *
 SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.
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