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Rat Anti-Mouse CD62L (L-selectin)

ANTIGEN DESCRIPTION
CD62L, also known as L-selectin, is a type I transmembrane glycoprotein with lectin-like and Epidermal Growth Factor-like domains.[1,2] It binds to sialylated oligosaccharide determinants on high endothelial venules (HEV) in peripheral lymph nodes.[1,2] In the mouse, CD62L is expressed on most thymocytes and on peripheral leukocytes, including B and T lymphocytes, neutrophils, monocytes and eosinophils.[3-7] This member of the selectin family of cell adhesion molecules appears to be required for lymphocyte homing to peripheral lymph nodes and for leukocyte extravasation at sites of inflammation.[1,2,7-9] Expression of CD62L on lymphocytes and neutrophils is rapidly down-regulated upon cell activation and the level of CD62L expression, along with other markers, distinguishes naive T cells from effector/memory T cells.[10-13] The monoclonal antibody MEL-14 blocks in vitro binding of lymphocytes to peripheral lymph node HEV and inhibits in vivo lymphocyte extravasation into peripheral lymph nodes and the late stages of leukocyte rolling.[1,2,7-9]
[Technical Bulletin / References ] Back to CD Markers and Other Cell Surface Proteins - Specificity Mouse
 Cat. No.Product DescriptionCloneSize
USD Price
Order Qty
1705-01
 
Rat Anti-Mouse CD62L/L-selectin-UNLB
MEL-14 0.5 mg
$192.00
1705-02
 
Rat Anti-Mouse CD62L/L-selectin-FITC
MEL-14 0.5 mg
$235.00
1705-08
 
Rat Anti-Mouse CD62L/L-selectin-BIOT
MEL-14 0.5 mg
$222.00
1705-09
 
Rat Anti-Mouse CD62L/L-selectin-R-PE
MEL-14 0.1 mg
$185.00
1705-09L
 
Rat Anti-Mouse CD62L/L-selectin-R-PE
MEL-14 0.2 mg
$245.00
1705-11
 
Rat Anti-Mouse CD62L/L-selectin-APC
MEL-14 0.1 mg
$198.00
1705-13
 
Rat Anti-Mouse CD62L/L-selectin-SPRD
MEL-14 0.1 mg
$198.00
1705-14
 
Rat Anti-Mouse CD62L/L-selectin-LE/AF
MEL-14 0.5 mg
$245.00
1705-17
 
Rat Anti-Mouse CD62L/L-selectin-PE/CY7
MEL-14 0.1 mg
$192.00
1705-19
 
Rat Anti-Mouse CD62L/L-selectin-APC/Cy7
MEL-14 0.1 mg
$222.00
1705-26
 
Rat Anti-Mouse CD62L/L-selectin-Pacific Blue
MEL-14 0.1 mg
$190.00
1705-30
 
Rat Anti-Mouse CD62L/L-selectin-Alexa Fluor 488
MEL-14 0.1 mg
$190.00
1705-31
 
Rat Anti-Mouse CD62L/L-selectin-Alexa Fluor 647
MEL-14 0.1 mg
$195.00
FORMAT ABBREVIATIONS:
UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
 CY3 - CyanineTM 3-labeled *
SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.