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Rat Anti-Human Caspase 2

DESCRIPTION
The Caspases are a family of cysteine proteases that induce apoptosis in response to a variety of intraand extracellular stimuli. These enzymes are synthesized as inactive precursors which become cleaved at aspartate-specific sites upon induction of apoptosis[2]. Caspase 2 (ICH-1/Nedd2) is an initiator caspase that is prevalent in both the cytosol and nucleus in many cell types[3]. During embryonic development it is expressed at relatively high levels in the central nervous system, liver, kidney and lungs and is prevalent in numerous tissues in adults[4,5]. Studies have shown that Caspase 2 becomes activated in response to several lethal stimuli including DNA damage, ER stress and death receptor stimulation and further evidence has suggested a role in reactive oxygen species-induced cell death[2,6-9].

The SB123a monoclonal antibody detects bands at ~40 and ~48 kD, corresponding to cleaved and uncleaved forms of Caspase 2, respectively.
[Technical Bulletin / References ] Back to Apoptosis Research - Pro-apoptosis
 Cat. No.Product DescriptionCloneSize
USD Price
Order Qty
17100-01
 
Rat Anti-Human Caspase 2-UNLB
SB123A 0.1 mg
$200.00
FORMAT ABBREVIATIONS:
UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
 CY3 - CyanineTM 3-labeled *
SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.