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Rat Anti-Mouse CD80 (B7-1)

ANTIGEN DESCRIPTION
CD80 (B7-1) is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed by dendritic cells, monocytes, and peritoneal macrophages. Expression of CD80 on B cells is upregulated after activation by various means including stimulation by LPS, IL-4, and surface Ig receptor cross linking with peak expression occurring between 48 and 72 hours postactivation. [1-4] The interaction of CD80/B7-1 with its ligands, CD28 and CD152/CTLA-4, provides a potent costimulatory signal for T cells activated through the CD3/T cell receptor complex.[5,6] The monoclonal antibody 1G10 blocks binding of CTLA-4 to CD80, but it does not block stimulation of T cells by natural antigenpresenting cells. [2,7]
[Technical Bulletin / References ] Back to CD Markers and Other Cell Surface Proteins - Specificity Mouse
 Cat. No.Product DescriptionCloneSize
USD Price
Order Qty
1730-01
 
Rat Anti-Mouse CD80/B7-1-UNLB
1G10 0.5 mg
$192.00
1730-02
 
Rat Anti-Mouse CD80/B7-1-FITC
1G10 0.5 mg
$235.00
1730-08
 
Rat Anti-Mouse CD80/B7-1-BIOT
1G10 0.5 mg
$222.00
1730-09
 
Rat Anti-Mouse CD80/B7-1-R-PE
1G10 0.1 mg
$185.00
1730-09L
 
Rat Anti-Mouse CD80/B7-1-R-PE
1G10 0.2 mg
$245.00
1730-11
 
Rat Anti-Mouse CD80/B7-1-APC
1G10 0.1 mg
$235.00
1730-13
 
Rat Anti-Mouse CD80/B7-1-SPRD
1G10 0.1 mg
$235.00
1730-14
 
Rat Anti-Mouse CD80/B7-1-LE/AF
1G10 0.5 mg
$240.00
FORMAT ABBREVIATIONS:
UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
 CY3 - CyanineTM 3-labeled *
SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.