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Rat Anti-Mouse Ly-6A/E (Sca-1)

ANTIGEN DESCRIPTION
Ly-6A/E, also known as Sca-1, is a member of the Ly-6 multigene family of type V glycophosphatidylinositol-anchored cell surface proteins.[1-3] It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly-6.1 and Ly-6.2 allotypes.[4-6] In the periphery, Ly-6A/E exhibits a pattern of expression which is based on differences between the two allotypes. Ly-6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have few Ly-6A/E+ resting peripheral lymphocytes, whereas Ly-6.2 strains (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have relatively high numbers of Ly-6A/E+ lymphocytes.[1,7-9] The expression of Ly-6A/E is dramatically upregulated in all strains upon cellular activation.[1,8,9] Studies with MAb D7 suggest that Ly-6A/E may be involved in B and T lymphocyte responses,9-12 and it appears that the antigen may be required for T-cell receptor-mediated T-cell activation.[3,13]
[Technical Bulletin / References ] Back to CD Markers and Other Cell Surface Proteins - Specificity Mouse
 Cat. No.Product DescriptionCloneSize
USD Price
Order Qty
1755-01
 
Rat Anti-Mouse Ly-6A/E-UNLB
D7 0.5 mg
$192.00
1755-02
 
Rat Anti-Mouse Ly-6A/E-FITC
D7 0.5 mg
$245.00
1755-08
 
Rat Anti-Mouse Ly-6A/E-BIOT
D7 0.5 mg
$222.00
1755-09
 
Rat Anti-Mouse Ly-6A/E-R-PE
D7 0.1 mg
$195.00
1755-09L
 
Rat Anti-Mouse Ly-6A/E-R-PE
D7 0.2 mg
$245.00
1755-11
 
Rat Anti-Mouse Ly-6A/E-APC
D7 0.1 mg
$222.00
1755-13
 
Rat Anti-Mouse Ly-6A/E-SPRD
D7 0.1 mg
$260.00
1755-14
 
Rat Anti-Mouse Ly-6A/E-LE/AF
D7 0.5 mg
$345.00
1755-16
 
Rat Anti-Mouse Ly-6A/E-PE/CY5.5
D7 0.1 mg
$240.00
1755-26
 
Rat Anti-Mouse Ly-6A/E-Pacific Blue
D7 0.1 mg
$190.00
1755-30
 
Rat Anti-Mouse Ly-6A/E-Alexa Fluor 488
D7 0.1 mg
$190.00
1755-31
 
Rat Anti-Mouse Ly-6A/E-Alexa Fluor 647
D7 0.1 mg
$190.00
FORMAT ABBREVIATIONS:
UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
 CY3 - CyanineTM 3-labeled *
SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.