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Rat Anti-Mouse CD49b (VLA-2α, Integrin α2)

ANTIGEN DESCRIPTION
The monoclonal antibody DX5 reacts with CD49b, also known as very late antigen-2 (VLA-2) and α2 integrin.[1] The antibody stains the majority of NK cells and a small subpopulation of T cells in all mouse strains tested (e.g., A/J, AKR, BALB/c, C3H/HeJ, C57BL/6, C57BL/10, C57BR, C58, CBA/Ca, CBA/J, DBA/1, DBA/2, SJL, SWR).[2.3] Three-color flow cytometry analysis has revealed that most cells that express NK-1.1 (NKR-P1C) also express CD49b. However, small subsets of DX5+NK-1.1- and DX5-NK- 1.1+ cells can be found, especially among the CD3+ population of T lymphocytes.[2] NK cells cultured in the presence of IL-2 progressively lose reactivity with DX5 as a consequence of cellular proliferation.[1] Therefore, DX5 can be used to define functionally distinct subsets of murine NK cells. The monoclonal antibody DX5 has not been demonstrated to have activating or blocking activity.[2]
[Technical Bulletin / References ] Back to CD Markers and Other Cell Surface Proteins - Specificity Mouse
 Cat. No.Product DescriptionCloneSize
USD Price
Order Qty
1806-01
 
Rat Anti-Mouse CD49b/VLA-2a-UNLB
DX5 0.5 mg
$212.00
1806-02
 
Rat Anti-Mouse CD49b/VLA-2a-FITC
DX5 0.5 mg
$245.00
1806-08
 
Rat Anti-Mouse CD49b/VLA-2a-BIOT
DX5 0.5 mg
$225.00
1806-09
 
Rat Anti-Mouse CD49b/VLA-2a-R-PE
DX5 0.1 mg
$175.00
1806-09L
 
Rat Anti-Mouse CD49b/VLA-2a-R-PE
DX5 0.2 mg
$255.00
1806-11
 
Rat Anti-Mouse CD49b/VLA-2a-APC
DX5 0.1 mg
$222.00
1806-14
 
Rat Anti-Mouse CD49b/VLA-2a-LE/AF
DX5 0.5 mg
$340.00
1806-19
 
Rat Anti-Mouse CD49b/VLA-2a-APC/CY7
DX5 0.1 mg
$255.00
FORMAT ABBREVIATIONS:
UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
 CY3 - CyanineTM 3-labeled *
SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.