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Hamster Anti-Mouse CD103 (integrin αIEL)

ANTIGEN DESCRIPTION
CD103 is a member of the integrin series of adhesion molecules. This antigen defines a developmentally important subset of T cells, namely mucosal T cells including all IEL (intraepithelial lymphocytes) and ~20% of lamina propria T cells. Expression of CD103 is more restricted outside these mucosal organs, appearing at lower levels on T cell subsets of the lymph node, dendritic epidermis and periphery.[1-3] In non-epithelial CD103+ T cells there is a bias toward expression on CD8+.cells. The 2E7 mAb exhibits antigen immunoprecipitation patterns similar if not identical to the rat anti-mouse CD103 mAb M290.[1] The 2E7 mAb is reported to have signal-inducing activity in a redirected lysis assay and to co-stimulate IEL and CD8+ lymph node cells in conjunction with anti-TCR in vitro, which runs counter to the usual inhibition of CTL by anti-integrins.[1] This co-stimulatory activity is also shared by the mAb M290.[4] The property of costimulation is not unique to the mouse since the combination of anti-human αIEL plus anti-TCR will produce similar proliferation in human cells, with the exception that CD8+ cells are not stimulated.[5]
[Technical Bulletin / References ] Back to CD Markers and Other Cell Surface Proteins - Specificity Mouse
 Cat. No.Product DescriptionCloneSize
USD Price
Order Qty
1810-01
 
Hamster Anti-Mouse CD103-UNLB
2E7 0.5 mg
$265.00
1810-02
 
Hamster Anti-Mouse CD103-FITC
2E7 0.5 mg
$300.00
1810-08
 
Hamster Anti-Mouse CD103-BIOT
2E7 0.5 mg
$275.00
1810-09
 
Hamster Anti-Mouse CD103-R-PE
2E7 0.1 mg
$178.00
1810-14
 
Hamster Anti-Mouse CD103-LE/AF
2E7 0.5 mg
$269.50
1810-26
 
Hamster Anti-Mouse CD103-Pacific Blue
2E7 0.1 mg
$190.00
1810-30
 
Hamster Anti-Mouse CD103-Alexa Fluor 488
2E7 0.1 mg
$190.00
1810-31
 
Hamster Anti-Mouse CD103-Alexa Fluor 647
2E7 0.1 mg
$190.00
FORMAT ABBREVIATIONS:
UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
 CY3 - CyanineTM 3-labeled *
SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.