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Rat Anti-Mouse CD117 (c-kit)

ANTIGEN DESCRIPTION
The CD117/c-kit antigen is the cell-surface receptor for Stem Cell Factor (SCF). Together these molecules constitute a ligand/receptor pair which functions to maintain normal hematopoiesis in the adult.[1-3] Signaling through SCF/c-kit has an important role in stimulating myeloid and erythroid roduction of primitive hematopoietic progenitor cells.[2] A variety of cytokines act synergistically with SCF to stimulate proliferation and differentiation of bone marrow progenitor cells. For example, SCF plus IL-7 can stimulate the combined myeloid and B-cell differentiation of uncommitted hematopoietic progenitor cells.[2] SCF/c-kit also participates in erythropoiesis in both the bone marrow and spleen.[1] Loss-of-function mutations for SCF/c-kit lead to a variety of pleiotropic developmental defects, while gain-of-function mutations can lead to constitutive activation of the kit receptor and links to cancer.[3] Examples of the former are mast cell deficiency and severe macrocytic anemia, while the latter mutation has been identified in mastocytomas.[3] Anti-CD117 mAbs have been used to block the function of the c-kit receptor in a variety of studies. These include the blockade of hematopoiesis[1,4] and disruption of melanocyte development.
[Technical Bulletin / References ] Back to CD Markers and Other Cell Surface Proteins - Specificity Mouse
 Cat. No.Product DescriptionCloneSize
USD Price
Order Qty
1880-01
 
Rat Anti-Mouse CD117/c-kit-UNLB
2B8 0.5 mg
$192.00
1880-02
 
Rat Anti-Mouse CD117/c-kit-FITC
2B8 0.5 mg
$235.00
1880-08
 
Rat Anti-Mouse CD117/c-kit-BIOT
2B8 0.5 mg
$225.00
1880-09
 
Rat Anti-Mouse CD117/c-kit-R-PE
2B8 0.1 mg
$155.00
1880-09L
 
Rat Anti-Mouse CD117/c-kit-R-PE
2B8 0.2 mg
$212.00
1880-11
 
Rat Anti-Mouse CD117/c-kit-APC
2B8 0.1 mg
$172.00
1880-13
 
Rat Anti-Mouse CD117/c-kit-SPRD
2B8 0.1 mg
$198.00
1880-14
 
Rat Anti-Mouse CD117/c-kit-LE/AF
2B8 0.5 mg
$275.00
1880-15
 
Rat Anti-Mouse CD117/c-kit-CY5
2B8 0.1 mg
$250.00
1880-18
 
Rat Anti-Mouse CD117/c-kit-UNLB
2B8 0.1 mg
$210.00
1880-19
 
Rat Anti-Mouse CD117/c-kit-APC/CY7
2B8 0.1 mg
$192.00
1880-30
 
Rat Anti-Mouse CD117/c-kit-Alexa Fluor 488
2B8 0.1 mg
$190.00
1880-31
 
Rat Anti-Mouse CD117/c-kit-Alexa Fluor 647
2B8 0.1 mg
$192.00
FORMAT ABBREVIATIONS:
UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
 CY3 - CyanineTM 3-labeled *
SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.