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Mouse Anti-Human TRAIL-UNLB (SB91c)
Cat. No.:
11050-01
Purified Anti-Human TRAIL antibody for use in ELISA assays.
$275.00
| Clone | SB91c |
|---|---|
| Isotype | Mouse (BALB/c) IgG2bκ |
| Isotype Control | Mouse IgG2b-UNLB (A-1) |
| Specificity | Human TRAIL |
| Alternative Names | CD253, Apo-2 ligand, Apo-2L, TNFSF10 |
| Description |
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family of cytokines. This type II transmembrane protein is expressed by several cytotoxic immune cells, including natural killer cells and activated T cells, and is selective for tumorigenic and virally infected cells. TRAIL can bind to DR4 and DR5 receptors on target cells which facilitates recruitment of numerous signaling proteins to form a death-inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of caspase-8. Numerous studies have identified TRAIL as a potent apoptotic factor in a variety of human cancer cell lines, but this cytokine does not appear to affect normal cell lines. Therefore, the selectivity and anti-tumorigenic properties of TRAIL make it an intriguing and potentially therapeutic agent in the treatment of cancer. |
| Immunogen | Recombinant TRAIL |
| Conjugate | UNLB (Unconjugated) |
| Buffer Formulation | Borate buffered saline, pH 8.2 |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C |
| Applications |
ELISA – Quality tested |
| RRID Number | AB_2794599 |
| Gene ID |
8743 (Human) |
| Gene ID Symbol |
TNFSF10 (Human) |
| Gene ID Aliases | APO2L; Apo-2L; CD253; TL2; TNLG6A; TRAIL |
| UniProt ID |
P50591 (Human) |
| UniProt Name |
TNF10_HUMAN (Human) |
Documentation
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