Rat Anti-Mouse CD38-Alexa Fluor® 647
Cat. No.
1640-31
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Size
0.1 mg
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Price (USD)
$190.00
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Clone |
90
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Isotype |
Rat IgG2aκ
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Isotype Control |
Rat IgG2a-Alexa Fluor® 647
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Immunogen |
Mouse bone marrow pre-B cells
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Specificity |
Mouse CD38
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Alternalte Name(s) |
T10, ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase
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Description |
Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR), and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral B-lineage cells and at low density on germinal center B cells from unimmunized mice. It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCRαβ+, CD4-, CD8-. Murine CD38 is also expressed by all Mac-1+ macrophages in the peritoneal cavities of unimmunized mice but not by unstimulated bone-marrow-derived macrophages. Monoclonal antibodies to CD38 have been shown to induce B and T cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis.
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Format/Conjugate |
AF647 (Alexa Fluor® 647)
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Buffer Formulation |
Phosphate buffered saline containing 0.1% sodium azide
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Concentration |
0.5 mg/mL
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Volume |
0.2 mL
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Storage & Handling |
2-8°C; Avoid exposure to light
Please refer to product specific SDS
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Applications |
Applications for relevant formats of this clone include - Flow Cytometry – Quality tested 1 Immunohistochemistry-Frozen Sections – Reported in literature 1 Immunoprecipitation – Reported in literature 1 Stimulation – Reported in literature 2
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Recommended Dilutions |
Please refer to product specific Technical Bulletin
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RRID |
AB_2795082
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Gene ID |
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Gene Symbol |
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Gene Aliases |
I-19; ADPRC 1; Cd38-rs1
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Uniprot ID |
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Uniprot Name |
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-
C57BL/6 mouse splenocytes were stained with Rat Anti-Mouse CD38-AF647 (SB Cat. No. 1640-31) and Rat Anti-Mouse CD3ε-FITC (SB Cat. No. 1535-02).
C57BL/6 mouse splenocytes were stained with Rat Anti-Mouse CD38-AF647 (SB Cat. No. 1640-31) and Rat Anti-Mouse CD3ε-FITC (SB Cat. No. 1535-02).
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References
1. | Oliver AM, Martin F, Kearney JF. Mouse CD38 is down-regulated on germinal center B cells and mature plasma cells. J Immunol. 1997;158:1108-15. (Immunogen, IP, IHC-FS, FC) | 2. | Etich J, Bergmeier V, Frie C, Kreft S, Bengestrate L, Eming S, et al. PECAM1+/Sca1+/CD38+ vascular cells transform into myofibroblast-like cells in skin wound repair. PLoS One. 2013;8(1):e53262. (Stim) |
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Alexa Fluor® is a registered trademark of Life Technologies Corporation
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