Rat Anti-Mouse CD38-Alexa Fluor® 647

Cat. No.
1640-31  
Size
0.1 mg   		Price (USD)
$190.00 
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Clone 90
Isotype Rat IgG2aκ
Isotype Control Rat IgG2a-Alexa Fluor® 647
Immunogen Mouse bone marrow pre-B cells
Specificity Mouse CD38
Alternalte Name(s) T10, ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase
Description Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR), and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral B-lineage cells and at low density on germinal center B cells from unimmunized mice. It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCRαβ+, CD4-, CD8-. Murine CD38 is also expressed by all Mac-1+ macrophages in the peritoneal cavities of unimmunized mice but not by unstimulated bone-marrow-derived macrophages. Monoclonal antibodies to CD38 have been shown to induce B and T cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis.
Format/Conjugate AF647 (Alexa Fluor® 647)
Buffer Formulation Phosphate buffered saline containing < 0.1% sodium azide
Concentration 0.5 mg/mL
Volume 0.2 mL
Storage & Handling 2-8°C; Avoid exposure to light
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
Flow Cytometry – Quality tested 1
Immunohistochemistry-Frozen Sections – Reported in literature 1
Immunoprecipitation – Reported in literature 1
Stimulation – Reported in literature 2
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2795082
Gene ID
12494 (Mouse)
Gene Symbol
Cd38 (Mouse)
Gene Aliases I-19; ADPRC 1; Cd38-rs1
Uniprot ID
P56528 (Mouse)
Uniprot Name
CD38_MOUSE 
  • Rat Anti-Mouse CD38-AF647
    C57BL/6 mouse splenocytes were stained with Rat Anti-Mouse CD38-AF647 (SB Cat. No. 1640-31) and Rat Anti-Mouse CD3ε-FITC (SB Cat. No. 1535-02).

C57BL/6 mouse splenocytes were stained with Rat Anti-Mouse CD38-AF647 (SB Cat. No. 1640-31) and Rat Anti-Mouse CD3ε-FITC (SB Cat. No. 1535-02).
 
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References
1. Oliver AM, Martin F, Kearney JF. Mouse CD38 is down-regulated on germinal center B cells and mature plasma cells. J Immunol. 1997;158:1108-15. (Immunogen, IP, IHC-FS, FC)
2. Etich J, Bergmeier V, Frie C, Kreft S, Bengestrate L, Eming S, et al. PECAM1+/Sca1+/CD38+ vascular cells transform into myofibroblast-like cells in skin wound repair. PLoS One. 2013;8(1):e53262. (Stim)
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