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Hamster Anti-Mouse CD11c-AF488 (N418)

Cat. No:
Alexa Fluor® 488 Anti-Mouse CD11c antibody for use in flow cytometry and immunohistochemistry assays.
Size Price (USD) Quantity
0.1 mg $199.00
More Information
Clone N418
Isotype Hamster (Armenian) IgG2
Isotype Control Hamster IgG-AF488
Specificity Mouse CD11c
Alternative Names p150, integrin αX, CR4, 95 α subunit, ITGAV
Description Also known as αX integrin, CR4, and p150, CD11c is primarily expressed on dendritic cells, NK cells, a subset of intestinal intraepithelial lymphocytes (IEL) and some activated T cells. CD11c and CD18 (β2 integrin) form a αXβ2 heterodimer that plays an important role in cell-cell contact by binding its ligands: iC3b, fibrinogen, and CD54.
Immunogen Mouse spleen dendritic cells
Conjugate AF488 (Alexa Fluor® 488)
Buffer Formulation Phosphate buffered saline containing < 0.1% sodium azide
Clonality Monoclonal
Concentration 0.5 mg/mL
Volume 0.2 mL
Recommended Storage 2-8°C; Avoid exposure to light
Trademark Information Alexa Fluor® is a registered trademark of Thermo Fisher Scientific, Inc. or its subsidiaries
Applications Flow Cytometry – Quality tested 1,3
Immunohistochemistry-Frozen Sections – Reported in literature 1,2
Electron Microscopy – Reported in literature 4
Immunoprecipitation – Reported in literature 1

RRID Number AB_2794936
Gene ID 16411 (Mouse)
Gene ID Symbol Itgax (Mouse)
Gene ID Aliases Cr4; N418; Cd11c; AI449405
UniProt ID Q9QXH4 (Mouse)
UniProt Name ITAX_MOUSE (Mouse)

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  1. 1. Metlay JP, Witmer-Pack M, Agger R, Crowley MT, Lawless D, Steinman RM. The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J Exp Med. 1990;171:1753-71. (Immunogen, FC, IHC-FC, IP)
  2. 2. Agger R, Witmer-Pack M, Romani N, Stossel H, Swiggard WJ, Metlay JP, et al. Two populations of splenic dendritic cells detected with M342, a new monoclonal to an intracellular antigen of interdigitating dendritic cells and some B lymphocytes. J Leukoc Biol. 1992;52:34-42. (IHC-FS)
  3. 3. Delong P, Tanaka T, Kruklitis R, Henry AC, Kapoor V, Kaiser LR, et al. Use of cyclooxygenase-2 inhibition to enhance the efficacy of immunotherapy. Cancer Res. 2003;63:7845-52. (FC)
  4. 4. Reis e Sousa C, Stahl PD, Austyn JM. Phagocytosis of antigens by Langerhans cells in vitro. J Exp Med. 1993;178:509-19. (EM)