Mouse Anti-Human GSK-3β-UNLB (3A11)
Purified Anti-GSK-3β antibody for use in ELISA and western blot assays.
|Isotype||Mouse (BALB/c) IgG2aκ|
|Isotype Control||Mouse IgG2a-UNLB (HOPC-1)|
|Alternative Names||Glycogen synthase kinase-3 beta|
|Description||Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3α and GSK-3β. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics, and cell motility.|
|Immunogen||Recombinant N-terminal GSK-3β|
|Buffer Formulation||Borate buffered saline, pH 8.2|
ELISA – Quality tested|
Immunoblotiing – Reported in literature 1
|Gene ID Symbol||
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- 1. Sun M, Song L, Li Y, Zhou T, Jope RS. Identification of an antiapoptotic protein complex at death receptors. Cell Death Differ. 2008;15:1887-1900. (WB)