Mouse Anti-Human TRAIL-BIOT (SB91a)
Biotin Anti-Human TRAIL antibody for use in ELISA assays.
|Isotype||Mouse (BALB/c) IgG2bκ|
|Isotype Control||Mouse IgG2b-BIOT (A-1)|
|Alternative Names||CD253, Apo-2 ligand, Apo-2L, TNFSF10|
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family of cytokines. This type II transmembrane protein is expressed by several cytotoxic immune cells, including natural killer cells and activated T cells, and is selective for tumorigenic and virally infected cells. TRAIL can bind to DR4 and DR5 receptors on target cells which facilitates recruitment of numerous signaling proteins to form a death-inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of caspase-8.
Numerous studies have identified TRAIL as a potent apoptotic factor in a variety of human cancer cell lines, but this cytokine does not appear to affect normal cell lines. Therefore, the selectivity and anti-tumorigenic properties of TRAIL make it an intriguing and potentially therapeutic agent in the treatment of cancer.
|Buffer Formulation||Phosphate buffered saline containing < 0.1% sodium azide|
ELISA – Quality tested|
|Gene ID Symbol||
|Gene ID Aliases||APO2L; Apo-2L; CD253; TL2; TNLG6A; TRAIL|