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Mouse Anti-Human TRAIL-BIOT (SB91a)

Cat. No.:
11040-08
Biotin Anti-Human TRAIL antibody for use in ELISA assays.
$290.00
Size Price (USD) Quantity
0.5 mg $290.00
More Information
Clone SB91a
Isotype Mouse (BALB/c) IgG2bκ
Isotype Control Mouse IgG2b-BIOT (A-1)
Specificity Human TRAIL
Alternative Names CD253, Apo-2 ligand, Apo-2L, TNFSF10
Description Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family of cytokines. This type II transmembrane protein is expressed by several cytotoxic immune cells, including natural killer cells and activated T cells, and is selective for tumorigenic and virally infected cells. TRAIL can bind to DR4 and DR5 receptors on target cells which facilitates recruitment of numerous signaling proteins to form a death-inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of caspase-8.

Numerous studies have identified TRAIL as a potent apoptotic factor in a variety of human cancer cell lines, but this cytokine does not appear to affect normal cell lines. Therefore, the selectivity and anti-tumorigenic properties of TRAIL make it an intriguing and potentially therapeutic agent in the treatment of cancer.
Immunogen Recombinant TRAIL
Conjugate BIOT (Biotin)
Buffer Formulation Phosphate buffered saline containing < 0.1% sodium azide
Clonality Monoclonal
Concentration 0.5 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C
Applications ELISA – Quality tested

RRID Number AB_2794598
Gene ID 8743 (Human)
Gene ID Symbol TNFSF10 (Human)
Gene ID Aliases APO2L; Apo-2L; CD253; TL2; TNLG6A; TRAIL
UniProt ID P50591 (Human)
UniProt Name TNF10_HUMAN (Human)

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