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Mouse Anti-Human TRAIL-UNLB (SB91a)

Cat. No.:
11040-01
Purified Anti-Human TRAIL antibody for use in ELISA assays.
$250.00
Size Price (USD) Quantity
0.5 mg $250.00
More Information
Clone SB91a
Isotype Mouse (BALB/c) IgG2bκ
Isotype Control Mouse IgG2b-UNLB (A-1)
Specificity Human TRAIL
Alternative Names CD253, Apo-2 ligand, Apo-2L, TNFSF10
Description Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family of cytokines. This type II transmembrane protein is expressed by several cytotoxic immune cells, including natural killer cells and activated T cells, and is selective for tumorigenic and virally infected cells. TRAIL can bind to DR4 and DR5 receptors on target cells which facilitates recruitment of numerous signaling proteins to form a death-inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of caspase-8.

Numerous studies have identified TRAIL as a potent apoptotic factor in a variety of human cancer cell lines, but this cytokine does not appear to affect normal cell lines. Therefore, the selectivity and anti-tumorigenic properties of TRAIL make it an intriguing and potentially therapeutic agent in the treatment of cancer.
Immunogen Recombinant TRAIL
Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Clonality Monoclonal
Concentration 0.5 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C
Applications ELISA – Quality tested

RRID Number AB_2794597
Gene ID 8743 (Human)
Gene ID Symbol TNFSF10 (Human)
Gene ID Aliases APO2L; Apo-2L; CD253; TL2; TNLG6A; TRAIL
UniProt ID P50591 (Human)
UniProt Name TNF10_HUMAN (Human)

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