Rat Anti-Mouse CD117-UNLB
Cat. No.
1885-01
|
Size
0.5 mg
|
Price (USD)
$192.00
|
| Clone |
3C1
|
| Isotype |
Rat (Wistar) IgG2bκ
|
| Isotype Control |
Rat IgG2b-UNLB
|
| Immunogen |
Mouse IL-3-dependent bone marrow mast cells
|
| Specificity |
Mouse CD117
|
| Alternalte Name(s) |
c-Kit, mast cell growth factor, stem cell factor, steel factor, SCF
|
| Description |
The CD117 (c-Kit) antigen is the cell-surface receptor for stem cell factor (SCF). Together these molecules constitute a ligand/receptor pair which functions to maintain normal hematopoiesis in the adult. Signaling through SCF/c-Kit has an important role in stimulating myeloid and erythroid production of primitive hematopoietic progenitor cells. A variety of cytokines act synergistically with SCF to stimulate proliferation and differentiation of bone marrow progenitor cells. For example, SCF plus IL-7 can stimulate the combined myeloid and B cell differentiation of uncommitted hematopoietic progenitor cells. SCF/c-Kit also participates in erythropoiesis in both the bone marrow and spleen. Loss-of-function mutations for SCF/c-Kit lead to a variety of pleiotropic developmental defects while gain-of-function mutations can lead to constitutive activation of the kit receptor and links to cancer. Examples of the former are mast cell deficiency and severe macrocytic anemia while the latter mutation has been identified in mastocytomas.
|
| Format/Conjugate |
UNLB (Unconjugated)
|
| Buffer Formulation |
Borate buffered saline, pH 8.2
|
| Concentration |
0.5 mg/mL
|
| Volume |
1.0 mL
|
| Storage & Handling |
2-8°C
Please refer to product specific SDS
|
| Applications |
Applications for relevant formats of this clone include - Flow Cytometry – Quality tested 1
Immunoprecipitation – Reported in literature 1
|
| Recommended Dilutions |
Please refer to product specific Technical Bulletin
|
| RRID |
AB_2795436
|
| Gene ID |
|
| Gene Symbol |
|
| Gene Aliases |
Bs; CD117; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W; c-KIT
|
| Uniprot ID |
|
| Uniprot Name |
|
|
|
-
BALB/c mouse bone marrow cells were stained with Rat Anti-Mouse CD117-BIOT (SB Cat. No. 1885-08) and Rat Anti-Mouse CD45R-PE (SB Cat. No. 1665-09) followed by Streptavidin-FITC (SB Cat. No. 7100-02).
BALB/c mouse bone marrow cells were stained with Rat Anti-Mouse CD117-BIOT (SB Cat. No. 1885-08) and Rat Anti-Mouse CD45R-PE (SB Cat. No. 1665-09) followed by Streptavidin-FITC (SB Cat. No. 7100-02).
|
References
| 1. | Ikuta K, Weissman IL. Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc Natl Acad Sci USA. 1992;89:1502-6. (Immunogen, FC, IP) |
|