Mouse Anti-Human Smac/DIABLO-UNLB

Cat. No.
11070-01  
Size
0.1 mg  
Price (USD)
$300.00 
Clone 2D12
Isotype Mouse (BALB/c) IgG2bκ
Isotype Control Mouse IgG2b-UNLB
Immunogen Recombinant Smac/DIABLO
Specificity Human Smac/DIABLO
Alternalte Name(s) SMAC3, DIABLO-S , FLJ10537, FLJ25049, 0610041G12Rik
Description Smac/DIABLO (second mitochondria-derived activator of caspase/direct IAP-binding protein with low PI) is a mitochondrial protein that functions as a regulatory component during apoptosis. It is encoded by a nuclear gene and is subsequently imported into the mitochondria where the N-terminus is removed generating the mature form of the molecule. Smac/DIABLO has been shown to neutralize the antiapoptotic effect of the inhibitor of apoptosis protein (IAP) family, a major group of apoptosis regulators that have been shown to directly block caspase activity thereby blocking apoptosis.
Format/Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Concentration 0.5 mg/mL
Volume 0.2 mL
Storage & Handling 2-8°C
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
ELISA – Quality tested
Western Blot 1
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2794600
Gene ID
56616 (Human)
Gene Symbol
DIABLO (Human)
Gene Aliases DFNA64; SMAC
Uniprot ID
Q9NR28 (Human)
Uniprot Name
  • Total cell lysates from Jurkat cells were resolved by electrophoresis, transferred to PVDF membrane, and probed with Mouse Anti-Human Smac/DIABLO-UNLB (SB Cat. No. 11070-01). Proteins were visualized using Goat Anti-Mouse IgG, Human ads-HRP (SB Cat. No. 1030-05) secondary antibody and chemiluminescent detection.

Total cell lysates from Jurkat cells were resolved by electrophoresis, transferred to PVDF membrane, and probed with Mouse Anti-Human Smac/DIABLO-UNLB (SB Cat. No. 11070-01). Proteins were visualized using Goat Anti-Mouse IgG, Human ads-HRP (SB Cat. No. 1030-05) secondary antibody and chemiluminescent detection.
 
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References
1. SouthernBiotech published data