Mouse Anti-Human Caspase-3-UNLB (SB71b)
Purified Anti-Human Caspase-3 antibody for use in western blot assays.
|Isotype||Mouse (BALB/c) IgG2aκ|
|Isotype Control||Mouse IgG2a-UNLB (HOPC-1)|
|Alternative Names||SPP32, Yama, apopain|
|Description|| The caspases are a family of cysteine proteases that induce apoptosis in response to a variety of intra- and extracellular stimuli. These enzymes are synthesized as inactive precursors which become cleaved at aspartate-specific sites upon induction of apoptosis. Caspase-3 is one of the best characterized caspases in terms of specificity and function in apoptosis. It is a ubiquitously expressed protein in mammals and is highly prevalent in cells with lymphocytic origins, indicating a regulatory role in the immune system. Caspase-3 plays a critical role during embryonic development by inducing morphogenetic cell death in the mammalian brain and has also been linked to chromatin condensation, DNA fragmentation, and blebbing. |
The SB71b monoclonal antibody detects endogenous levels of full length caspase-3 (35 kDa) and the large fragment of caspase-3 resulting from cleavage (17 kDa).
|Immunogen||Recombinant human caspase-3|
|Buffer Formulation||Borate buffered saline, pH 8.2|
|Applications|| Western Blot – Quality tested|
|Gene ID|| 836 (Human) |
|Gene ID Symbol|| CASP3 (Human) |
|Gene ID Aliases||CPP32; CPP32B; SCA-1|
|UniProt ID|| P42574 (Human) |
|UniProt Name|| CASP3_HUMAN (Human) |