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Rat Anti-Mouse CD45-PE/TXRD (I3/2.3)

Cat. No.:
1660-10
PE/Texas Red Anti-Mouse CD45 antibody for use in flow cytometry assays.
$250.00
Size Price (USD) Quantity
0.1 mg $250.00
More Information
Clone I3/2.3
Isotype Rat (Lewis) IgG2bλ
Isotype Control Rat IgG2b-PE/TXRD (KLH/G2b-1-2)
Specificity Mouse CD45
Alternative Names LCA, leukocyte common antigen, T200, Ly-5, Receptor-type tyrosine-protein phosphatase C, Lyt-4, Ptprc
Description CD45 is the common leukocyte antigen and is expressed on all cells of hematopoietic origin except erythrocytes. CD45 exists as a number of different isoforms which result from alternative RNA splicing of exons 4, 5 and 6. The I3/2.3 monoclonal antibody recognizes a framework epitope present on all CD45 isoforms. The CD45 molecule has been implicated as playing a key role in thymic development and in antigen-driven proliferation of T cells.
Immunogen T1M1 (Thy-1c) cells
Conjugate PE/TXRD (R-phycoerythrin/Texas Red®)
Buffer Formulation Phosphate buffered saline containing < 0.1% sodium azide and a stabilizer
Clonality Monoclonal
Concentration 0.1 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C; Avoid exposure to light; Do not freeze
Trademark Information Texas Red® is a registered trademark of Thermo Fisher Scientific, Inc. or its subsidiaries
Applications Flow Cytometry – Quality tested 2,5-7
Immunohistochemistry-Frozen Sections – Reported in literature 3,4
Immunoprecipitation – Reported in literature 1,2

RRID Number AB_2795101
Gene ID 19264 (Mouse)
Gene ID Symbol Ptprc (Mouse)
Gene ID Aliases loc; B220; Cd45; L-CA; Ly-5; T200; CD45R; Lyt-4
UniProt ID P06800 (Mouse)
UniProt Name PTPRC_MOUSE (Mouse)

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  1. 1. Trowbridge IS. Interspecies spleen-myeloma hybrid producing monoclonal antibodies against mouse lymphocyte surface glycoprotein, T200. J Exp Med. 1978;148:313-23. (Immunogen, IP)
  2. 2. Haidl ID, Ng DH, Rothenberger S, Johnson P, Jefferies WA. Detection of restricted isoform expression and tyrosine phosphatase activity of CD45 in murine dendritic cells. Eur J Immunol. 1995;25:3370-4. (FC, IP)
  3. 3. Craner MJ, Damarjian TG, Liu S, Hains BC, Lo AC, Black JA, et al. Sodium channels contribute to microglia/macrophage activation and function in EAE and MS. Glia. 2005;49:220-9. (IHC-FS)
  4. 4. Villalta SA, Lang J, Kubeck S, Kabre B, Szot GL, Calderon B, et al. Inhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet function. Diabetes. 2013;62:2870-8. (IHC-FS)
  5. 5. Takedachi M, Qu D, Ebisuno Y, Oohara H, Joachims ML, McGee ST, et al. CD73-generated adenosine restricts lymphocyte migration into draining lymph nodes. J Immunol. 2008;180:6288-96. (FC)
  6. 6. Matsunaga H, Hokari R, Kurihara C, Okada Y, Takebayashi K, Okudaira K, et al. Omega-3 fatty acids exacerbate DSS-induced colitis through decreased adiponectin in colonic subepithelial myofibroblasts. Inflamm Bowel Dis. 2008;14:1348-57. (FC)
  7. 7. Domingos-Pereira S, Decrausaz L, Derré L, Bobst M, Romero P, Schiller JT, et al. Intravaginal TLR agonists increase local vaccine-specific CD8 T cells and human papillomavirus-associated genital-tumor regression in mice. Mucosal Immunol. 2013;6:393-404. (FC)
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