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Hamster Anti-Mouse TCRγδ-AF488 (UC7-13D5)
Cat. No.:
1780-30
Alexa Fluor® 488 Anti-Mouse TCRγ/δ antibody for use in flow cytometry assays.
$230.00
| Clone | UC7-13D5 |
|---|---|
| Isotype | Hamster (Armenian) IgG3 |
| Isotype Control | Hamster IgG-AF488 |
| Specificity | Mouse TCRγδ |
| Description | The TCRγδ heterodimer of the CD3/T cell receptor complex is clonotypic and consists of Ig-like variable and constant domains. It is expressed during thymopoiesis and on the small subpopulation of γδ TCR-expressing T lymphocytes in the periphery. The majority of T cells present in some epithelial tissues are γδ+ and have limited receptor diversity. The TCRγδ heterodimer recognizes peptide antigen bound to MHC antigens and subsequent signal transduction mediated by the invariant chains leads to T cell activation. The monoclonal antibody UC7-13D5 is specific for the γδ heterodimer and plate-bound UC7-13D5 activates γδ TCR-bearing cells. This antibody does not react with αβ TCR-expressing T cells. |
| Immunogen | Mouse T cell clone G8 |
| Conjugate | AF488 (Alexa Fluor® 488) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/mL |
| Volume | 0.2 mL |
| Recommended Storage | 2-8°C; Avoid exposure to light |
| Trademark Information | Alexa Fluor® is a registered trademark of Thermo Fisher Scientific, Inc. or its subsidiaries |
| Applications |
Flow Cytometry – Quality tested 6 Immunoprecipitation – Reported in literature 1,2 Costimulation – Reported in literature 1,5 Depletion – Reported in literature 3,4 |
| RRID Number | AB_2795277 |
| Gene ID |
110067 (Mouse) 110066 (Mouse) |
| Gene ID Symbol |
Tcrg (Mouse) Tcrd (Mouse) |
| Gene ID Aliases | TCRGV1S1; TCRGV2S1; TCRGV3S1; TCRGV5S3; Tcrdelta |
Documentation
Certificate of Analysis Lookup
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- 1. Bluestone JA, Cron RQ, Barrett TA, Houlden B, Sperling AI, Dent A, et al. Repertoire development and ligand specificity of murine TCRγδ cells. Immunol Rev. 1991;120:5-33. (IP, Costim)
- 2. Belles C, Kuhl AL, Donoghue AJ, Sano Y, O'Brien RL, Born W, et al. Bias in the γδ T cell response to Listeria monocytogenes. Vδ6.3+ cells are a major component of the γδ T cell response to Listeria monocytogenes. J Immunol. 1996;156:4280-9. (IP)
- 3. Hiromatsu K, Yoshikai Y, Matsuzaki G, Ohga S, Muramori K, Matsumoto K, et al. A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice. J Exp Med. 1992;175:49-56. (Depletion)
- 4. Shibata K, Yamada H, Hara H, Kishihara K, Yoshokai Y. Resident Vδ1+ γδ T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production. J Immunol. 2007;178:4466-72. (Depletion)
- 5. Sperling AI, Linsley PS, Barrett TA, Bluestone JA. CD28-mediated costimulation is necessary for the activation of T cell receptor-γδ+ T lymphocytes. J Immunol. 1993;151:6043-50. (Costim)
- 6. Conrad ML, Davis WC, Koop BF. TCR and CD3 antibody cross-reactivity in 44 species. Cytometry. 2007;71A:925-33. (FC, Woodland Caribou Reactivity)
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