Rat Anti-Mouse CD94-FITC

Cat. No.
1809-02  
Size
0.5 mg  
Price (USD)
$245.00 
Clone 18d3
Isotype Rat (Lewis) IgG2aκ
Isotype Control Rat IgG2a-FITC
Immunogen CHO cells transfected with the B6 allele of CD94
Specificity Mouse CD94
Alternalte Name(s) Kp43, KLRD1
Description The monoclonal antibody 18d3 reacts with the mouse CD94 receptor subunit, a type II transmembrane glycoprotein. CD94 is expressed on the surface of NK cells, NK T cells, and some memory phenotype CD8+ cells. When CD94 is paired with NKG2A, C, or E subunit, it binds the nonclassical MHC class Ib molecule Qa-1b and results in a CD94high population by flow cytometry. Approximately half of NK cells do not express NKG2A, C or E; these cells express CD94 on the surface in a form that does not bind Qa-1b and is believed to be nonfunctional, producing a CD94low population by flow cytometry. CD94 is thought to play a role in the adhesion and activation of the NK cell lineage.
Format/Conjugate FITC (Fluorescein)
Buffer Formulation Phosphate buffered saline containing 0.1% sodium azide
Concentration 0.5 mg/mL
Volume 1.0 mL
Storage & Handling 2-8°C; Avoid exposure to light
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
Flow Cytometry – Quality tested 1-3
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2795373
Gene ID
16643 (Mouse)
Gene Symbol
Klrd1 (Mouse)
Gene Aliases CD94
Uniprot ID
O54707 (Mouse)
Uniprot Name
  • NK1.1 positive / CD3 negative C57BL/6 mouse splenocytes were stained with Rat Anti-Mouse CD94-FITC (SB Cat. No. 1809-02).

NK1.1 positive / CD3 negative C57BL/6 mouse splenocytes were stained with Rat Anti-Mouse CD94-FITC (SB Cat. No. 1809-02).
 
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References
1. Vance RE, Jamieson AM, Raulet DH. Recognition of the class Ib molecule Qa-1b by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells. J Exp Med. 1999;190:1801-12. (Immunogen, FC)
2. Beyersdorf NB, Ding X, Karp K, Hanke T. Expression of inhibitory "killer cell lectin-like receptor G1" identifies unique subpopulations of effector and memory CD8 T cells. Eur J Immunol. 2001;31:3443-52. (FC)
3. Vance RE, Jamieson AM, Cado D, Raulet DH. Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation. Proc Natl Acad Sci USA. 2002;99:868-73. (FC)