Rat Anti-Mouse CD105-Pacific Blue™

Cat. No.
1860-26  
Size
0.1 mg  
Price (USD)
$190.00 
Clone MJ7/18
Isotype Rat IgG2aκ
Isotype Control Rat IgG2a-Pacific Blue™
Immunogen Inflamed mouse skin
Specificity Mouse CD105
Alternalte Name(s) Endoglin
Description CD105, also known as endoglin, is a disulfide-linked type II transmembrane homodimer that is predominantly expressed on vascular endothelial cells. It is also found on pre-erythroblasts, macrophages, and lymphoid and myeloid leukemic cells. Both mouse and human CD105 exhibit >70% sequence homology in their cytoplasmic domains with type III transforming growth factor β (TGFβ) receptor. CD105 has been shown to be one of several receptors for the various isoforms of TGFβ which in turn is one of a family of proteins involved in regulation of cell differentiation, migration of cells, and control of the immune response.
Format/Conjugate PACBLU (Pacific Blue™)
Buffer Formulation Phosphate buffered saline containing 0.1% sodium azide
Concentration 0.5 mg/mL
Volume 0.2 mL
Storage & Handling 2-8°C; Avoid exposure to light
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
Flow Cytometry – Quality tested 2,7-9
Immunohistochemistry-Frozen Sections – Reported in literature 6
Immunoprecipitation – Reported in literature 2
Western Blot – Reported in literature 1,2,4,5
Separation – Reported in literature 3
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2795412
Gene ID
13805 (Mouse)
Gene Symbol
Eng (Mouse)
Gene Aliases Endo; CD105; AI528660; AI662476; S-endoglin
Uniprot ID
Q63961 (Mouse)
Uniprot Name
  • BALB/c mouse endothelioma cell line bEnd.3 was stained with Rat Anti-Mouse CD105-PACBLU (SB Cat. No. 1860-26).

BALB/c mouse endothelioma cell line bEnd.3 was stained with Rat Anti-Mouse CD105-PACBLU (SB Cat. No. 1860-26).
 
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References
1. Ge AZ, Butcher EC. Cloning and expression of a cDNA encoding mouse endoglin, an endothelial cell TGF-β ligand. Gene. 1994;138:201-6. (Immunogen, WB, FC)
2. Raab U, Velasco B, Lastres P, Letamendía A, Calés C, Langa C, et al. Expression of normal and truncated forms of human endoglin. Biochem J. 1999;339:579-88. (FC, WB, IP)
3. Finkensieper A, Kieser S, Bekhite MM, Richter M, Mueller JP, Graebner R, et al. The 5-lipoxygenase pathway regulates vasculogenesis in differentiating mouse embryonic stem cells. Cardiovasc Res. 2010;86:37-44. (Sep)
4. Belik J, Jerkic M, McIntyre BA, Pan J, Leen J, Yu LX, et al. Age-dependent endothelial nitric oxide synthase uncoupling in pulmonary arteries of endoglin heterozygous mice. Am J Physiol Lung Cell Mol Physiol. 2009;297:L1170-8. (WB)
5. Jerkic M, Peter M, Ardelean D, Fine M, Konerding MA, Letarte M. Dextran sulfate sodium leads to chronic colitis and pathological angiogenesis in endoglin heterozygous mice. Inflamm Bowel Dis. 2010;16:1859-70. (WB)
6. Wickersheim A, Kerber M, de Miguel LS, Plate KH, Machein MR. Endothelial progenitor cells do not contribute to tumor endothelium in primary and metastatic tumors. Int J Cancer. 2009;125:1771-7. (IHC-FS)
7. Ren Y, Finckenstein FG, Abdueva DA, Shahbazian V, Chung B, Weinberg KI, et al. Mouse mesenchymal stem cells expressing PAX-FKHR form alveolar rhabdomyosarcomas by cooperating with secondary mutations. Cancer Res. 2008;68:6587-97. (FC)
8. Adhikari AS, Agarwal N, Wood BM, Porretta C, Ruiz B, Pochampally RR, et al. CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance. Cancer Res. 2010;70:4602-12. (FC)
9. Moorthy RK, Sam GA, Kumar SV, Chacko G, Mathews V, Chacko AG, et al. Intralesional mesenchymal stromal cell transplant in a rodent model of cortical cryoinjury. Neurol India. 2011;59:573-8. (FC)
Pacific Blue™ is a trademark of Life Technologies Corporation