Mouse Anti-Human MMP-1-BIOT

Cat. No.
12011-08  
Size
0.1 mg  
Price (USD)
$210.00 
Clone SB12e
Isotype Mouse (BALB/c) IgG2bκ
Isotype Control Mouse IgG2b-BIOT
Immunogen Recombinant full length MMP-1
Specificity Human/Rabbit MMP-1
Alternalte Name(s) Matrix metalloproteinase 1, collagenase 1, interstitial collagenase, fibroblast collagenase
Description Matrix metalloproteinases (MMPs) are a family of at least 23 structurally related, zinc-containing enzymes that have the ability to breakdown connective tissue. MMP-1 has shown substrate specificity to collagens types I, II, III, VII, VIII, X, and XI as well as additional extracellular matrix components including gelatin, fibronectin, laminin, and proteoglycan.
Format/Conjugate BIOT (Biotin)
Buffer Formulation Phosphate buffered saline containing 0.1% sodium azide
Concentration 0.5 mg/mL
Volume 0.2 mL
Storage & Handling 2-8°C
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
ELISA – Quality tested 1
Immunohistochemistry-Paraffin Sections – Reported in literature 2,3
Immunohistochemistry-Frozen Sections – Reported in literature 4,5
Immunocytochemistry 14
Western Blot – Reported in literature 6-12
Multiplex – Reported in literature 13
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2794700
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References
1. Attia E, Bohnert K, Brown H, Bhargava M, Hannafin JA. Characterization of total and active matrix metalloproteinases-1, -3, and -13 synthesized and secreted by anterior cruciate ligament fibroblasts in three-dimensional collagen gels. Tissue Eng Part A. 2014;20:171-7. (ELISA, Rabbit Reactivity)
2. Singh M, Kindelberger D, Nagymanyoki Z, Ng S, Quick CM, Elias KM, et al. Matrix metalloproteinases and their inhibitors and inducer in gestational trophoblastic diseases and normal placenta. Gynecol Oncol. 2011;122:178-82. (IHC-PS)
3. Austin KM, Nguyen N, Javid G, Covic L, Kuliopulos A. Noncanonical matrix metalloprotease-1-protease-activated receptor-1 signaling triggers vascular smooth muscle cell dedifferentiation and arterial stenosis. J Biol Chem. 2013;288:23105-15. (IHC-PS)
4. Lama P, Le Maitre CL, Dolan P, Tarlton JF, Harding IJ, Adams MA. Do intervertebral discs degenerate before they herniate, or after?. Bone Joint J. 2013;95-B:1127-33. (IHC-FS)
5. Wolk K, Mitsui H, Witte K, Gellrich S, Gulati N, Humme D, et al. Deficient cutaneous antibacterial competence in cutaneous T-cell lymphomas: role of Th2-mediated biased Th17 function. Clin Cancer Res. 2014;20:5507-16. (IHC-FS)
6. Titeux M, Pendaries V, Tonasso L, Décha A, Bodemer C, Hovnanian A. A frequent functional SNP in the MMP1 promoter is associated with higher disease severity in recessive dystrophic epidermolysis bullosa. Hum Mutat. 2008;29:267-76. (WB)
7. Prato M, D'Alessandro S, Van den Steen PE, Opdenakker G, Arese P, Taramelli D, et al. Natural haemozoin modulates matrix metalloproteinases and induces morphological changes in human microvascular endothelium. Cell Microbiol. 2011;13:1275-85. (WB)
8. Garamszegi N, Garamszegi SP, Scully SP. Matrix metalloproteinase-1 contribution to sarcoma cell invasion. J Cell Mol Med. 2012;16:1331-41. (WB)
9. Chang Z, Kishimoto Y, Hasan A, Welham NV. TGF-β3 modulates the inflammatory environment and reduces scar formation following vocal fold mucosal injury in rats. Dis Model Mech. 2014;7:83-91. (WB)
10. Gregori J, Méndez O, Katsila T, Pujals M, Salvans C, Villarreal L, et al. Enhancing the biological relevance of secretome-based proteomics by linking tumor cell proliferation and protein secretion. J Proteome Res. 2014;13:3706-21. (WB)
11. Pickard A, McDade SS, McFarland M, McCluggage WG, Wheeler CM, McCance DJ. HPV16 down-regulates the insulin-like growth factor binding protein 2 to promote epithelial Invasion in organotypic cultures. PLoS Pathog. 2015;11(6):e1004988. (WB)
12. Shu Z, Shi X, Nie D, Guan B. Low-molecular-weight fucoidan inhibits the viability and invasiveness and triggers apoptosis in IL-1β-treated human rheumatoid arthritis fibroblast synoviocytes. Inflammation. 2015;38:1777-86. (WB)
13. Fabre V, Wu H, PondTor S, Coutinho H, Acosta L, Jiz M, et al. Tissue inhibitor of matrix-metalloprotease-1 predicts risk of hepatic fibrosis in human Schistosoma japonicum infection. J Infect Dis. 2011;203:707-14. (Multiplex)
14. SouthernBiotech published data (ICC)