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Hamster Anti-Mouse CD152-LE/AF (9H10)

Cat. No.:
1791-14
Low Endotoxin/Azide Free Anti-Mouse CD152 antibody for use in flow cytometry, ELISA, blocking, and costimulation assays.
$245.00
Size Price (USD) Quantity
0.5 mg $245.00
More Information
Clone 9H10
Isotype Hamster (Syrian) IgG2
Isotype Control Hamster IgG-LE/AF
Specificity Mouse CD152
Alternative Names CTLA-4, cytotoxic T-lymphocyte protein 4
Description CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28. Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80 and CD86) on antigen-presenting cells. CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T cell stimulation via the T cell receptor (TCR) complex. Whereas CD28 provides a positive costimulatory signal, CD152 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signaling through the TCR through its association with tyrosine phosphatases such as SHP-2.
Immunogen Heat-killed Staphylococcus A bacteria coated with mouse CTLA-4/human IgG1 fusion protein
Conjugate LE/AF (Low Endotoxin/Azide Free)
Buffer Formulation Phosphate buffered saline, pH 7.4
Clonality Monoclonal
Concentration 0.5 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C; Handle under aseptic conditions
Applications ELISA – Quality tested 3
Flow Cytometry – Reported in literature 1
Immunoprecipitation – Reported in literature 2
Costimulation – Reported in literature 1
Blocking – Reported in literature 1,4

RRID Number AB_2795297
Gene ID 12477 (Mouse)
Gene ID Symbol Ctla4 (Mouse)
Gene ID Aliases Cd152; Ly-56; Ctla-4
UniProt ID P09793 (Mouse)
UniProt Name CTLA4_MOUSE (Mouse)

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  1. 1. Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med. 1995;182:459-65. (Immunogen, FC, Costim, Block)
  2. 2. Zhang Y, Allison JP. Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. Proc Natl Acad Sci USA. 1997;94:9273-78. (IP)
  3. 3. Ward FJ, Dahal LN, Wijesekera SK, Abdul-Jawad SK, Kaewarpai T, Xu H, et al. The soluble isoform of CTLA-4 as a regulator of T-cell responses. Eur J Immunol. 2013;43:1274-85. (ELISA)
  4. 4. Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science. 1996;271:1734-36. (Block)