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Mouse Anti-Chicken MCAM-UNLB (C264)

Cat. No.:
Purified Anti-Chicken MCAM antibody for use in flow cytometry, immunocytochemistry, and immunoprecipitation assays.
Size Price (USD) Quantity
0.5 mg $264.00
More Information
Clone C264
Isotype Mouse (BALB/c) IgG2bκ
Isotype Control Mouse IgG2b-UNLB (A-1)
Specificity Chicken/Turkey MCAM
Alternative Names CD146, HEMCAM, melanoma cell adhesion molecule
Description Chicken MCAM, a member of the immunoglobulin superfamily of cell surface receptors, consists of the V-V-C2-C2-C2 Ig domains. It is a single chain glycoprotein with three mRNA splice variants. One has a short cytoplasmic tail, another has a long tail, and the third seems to lack transmembrane and cytoplasmic regions. It is highly homologous to gicerin, a molecule involved in neurite outgrowth and Wilm’s kidney tumor progression in the chicken, and to the human melanoma progression molecule MUC18. Chicken MCAM is expressed by c-kit+ hematopoietic progenitor cells in embryonic bone marrow, thymocytes, and capillary endothelial cells. MCAM-expressing cells sorted from bone marrow are enriched in progenitors capable of differentiating into T cells when transferred into the appropriate thymic microenvironment. MCAM has been proposed to be involved in cellular adhesion and homing processes.
Immunogen Mixture of E15 and E16 thymocytes from H.B15, H.B19, and H.B21 chicken embryos
Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Clonality Monoclonal
Concentration 0.5 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C
Applications Flow Cytometry – Quality tested 1-8
Immunocytochemistry – Reported in literature 1
Immunoprecipitation – Reported in literature 1,2

RRID Number AB_2796533
Gene ID 448832 (Chicken)
100549798 (Turkey)
Gene ID Symbol MCAM (Chicken)
MCAM (Turkey)

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  1. 1. Vainio O, Dunon D, Aïssi F, Dangy J, McNagny KM, Imhof BA. HEMCAM, an adhesion molecule expressed by c-kit+ hemopoietic progenitors. J Cell Biol. 1996;135:1655-68. (Immunogen, ICC, IP, FC)
  2. 2. Alais S, Allioli N, Pujades C, Duband J, Vainio O, Imhof BA, et al. HEMCAM/CD146 downregulates cell surface expression of β1 integrins. J Cell Sci. 2001;114:1847-59. (FC, IP)
  3. 3. Lampisuo M, Katevuo K, Lassila O. Antigenic phenotype of early intra-embryonic lymphoid progenitors in the chicken. Scand J Immunol. 1998;48:52-8. (FC)
  4. 4. Lampisuo M, Liippo J, Vainio O, McNagny KM, Kulmala J, Lassila O. Characterization of prethymic progenitors within the chicken embryo. Int Immunol. 1999;11:63-9. (FC)
  5. 5. Dunon D, Alliolo N, Vainio O, Ody C, Imhof BA. Quantification of T-cell progenitors during ontogeny: thymus colonization depends on blood delivery of progenitors. Blood. 1999;93:2234-43. (FC)
  6. 6. Guezguez B, Vigneron P, Alais S, Jaffredo T, Gavard J, Mège R, et al. A dileucine motif targets MCAM-l cell adhesion molecule to the basolateral membrane in MDCK cells. FEBS Lett. 2006;580:3649-56. (FC)
  7. 7. Guezguez B, Vigneron P, Lamerant N, Kieda C, Jaffredo T, Dunon D. Dual role of melanoma cell adhesion molecule (MCAM)/CD146 in lymphocyte endothelium interaction: MCAM/CD146 promotes rolling via microvilli induction in lymphocyte and is an endothelial adhesion receptor. J Immunol. 2007;179:6673-85. (FC)
  8. 8. Meyerhoff RR, Ali RA, Liu K, Huang G, Koci MD. Comprehensive analysis of commercially available mouse antichicken monoclonal antibodies for cross-reactivity with peripheral blood leukocytes from commercial turkeys. Poult Sci. 2012;91:383-92. (FC, Turkey Reactivity)
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