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Mouse Anti-Human Bid-UNLB (SB50a)

Cat. No.:
Purified Anti-Human Bid antibody for use in ELISA, western blot, and immunoprecipitation assays.
Size Price (USD) Quantity
0.1 mg $248.00
More Information
Clone SB50a
Isotype Mouse (BALB/c) IgG2bκ
Isotype Control Mouse IgG2b-UNLB (A-1)
Specificity Human Bid
Alternative Names Apoptic death agonist, BH3 domain-only protein, BH3 interacting domain death agonist
Description Members of the Bcl-2 family are pro- or antiapoptotic proteins that process one or several of the Bcl-2 homology (BH) domains. Bid is a proapoptotic, BH3-domain-only member or BH3-only protein (BOP) of the Bcl-2 family. Bid is localized in the cytosolic fraction of living cells as an inactive precursor. Activation of Bid occurs upon its cleavage by caspase-8 in the Fas and TNF-α apoptotic signaling pathways. Recent studies have suggested that Bid is also cleaved and activated by granzyme B, calpain and lysosomal extracts. Cleaved Bid translocates to mitochondria where it induces the release of cytochrome c from the intermembrane space of the mitochondria. The release of cytochrome c initiates apoptosis by activating downstream caspases through binding to Apaf-1. Bid has also been shown to interact with with Bax, another Bcl-2 family protein, to trigger a conformational change in Bax leading to the dimerization and integration of Bax into the outer mitochondrial membrane and activating the release of cytochrome c.
Immunogen Recombinant Bid
Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Clonality Monoclonal
Concentration 0.5 mg/mL
Volume 0.2 mL
Recommended Storage 2-8°C
Applications ELISA – Quality tested
Western Blot – Quality tested
Immunoprecipitation 1

RRID Number AB_2794562
Gene ID 637 (Human)
Gene ID Symbol BID (Human)
Gene ID Aliases FP497
UniProt ID P55957 (Human
UniProt Name BID_HUMAN (Human)

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  1. 1. SouthernBiotech unpublished data