Mouse Anti-Human Bid-UNLB (SB50a)
Cat. No.:
10951-01
Purified Anti-Human Bid antibody for use in ELISA, western blot, and immunoprecipitation assays.
$248.00
Clone | SB50a |
---|---|
Isotype | Mouse (BALB/c) IgG2bκ |
Isotype Control | Mouse IgG2b-UNLB (A-1) |
Specificity | Human Bid |
Alternative Names | Apoptic death agonist, BH3 domain-only protein, BH3 interacting domain death agonist |
Description | Members of the Bcl-2 family are pro- or antiapoptotic proteins that process one or several of the Bcl-2 homology (BH) domains. Bid is a proapoptotic, BH3-domain-only member or BH3-only protein (BOP) of the Bcl-2 family. Bid is localized in the cytosolic fraction of living cells as an inactive precursor. Activation of Bid occurs upon its cleavage by caspase-8 in the Fas and TNF-α apoptotic signaling pathways. Recent studies have suggested that Bid is also cleaved and activated by granzyme B, calpain and lysosomal extracts. Cleaved Bid translocates to mitochondria where it induces the release of cytochrome c from the intermembrane space of the mitochondria. The release of cytochrome c initiates apoptosis by activating downstream caspases through binding to Apaf-1. Bid has also been shown to interact with with Bax, another Bcl-2 family protein, to trigger a conformational change in Bax leading to the dimerization and integration of Bax into the outer mitochondrial membrane and activating the release of cytochrome c. |
Immunogen | Recombinant Bid |
Conjugate | UNLB (Unconjugated) |
Buffer Formulation | Borate buffered saline, pH 8.2 |
Clonality | Monoclonal |
Concentration | 0.5 mg/mL |
Volume | 0.2 mL |
Recommended Storage | 2-8°C |
Applications |
ELISA – Quality tested Western Blot – Quality tested Immunoprecipitation 1 |
RRID Number | AB_2794562 |
Gene ID |
637 (Human) |
Gene ID Symbol |
BID (Human) |
Gene ID Aliases | FP497 |
UniProt ID |
P55957 (Human |
UniProt Name |
BID_HUMAN (Human) |
Documentation
Certificate of Analysis Lookup
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- 1. SouthernBiotech unpublished data