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Mouse Anti-Human CD51-UNLB (13C2)

Cat. No.:
Purified Anti-Human CD51 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, ELISA, purification, depletion, adhesion, and blocking assays.
Size Price (USD) Quantity
0.1 mg $108.00
More Information
Clone 13C2
Isotype Mouse (BALB/c) IgG1κ
Isotype Control Mouse IgG1-UNLB (15H6)
Specificity Human/African Green Monkey/Rabbit/Bovine CD51
Alternative Names Integrin αV, vitronectin receptor, VNR-α chain
Description CD51 represents the integrin αV chain that associates with integrin β3 (CD61) to form the CD51/CD61 vitronectin receptor on endothelial cells, certain activated leukocytes, NK cells, macrophages, neutrophils, and platelets. CD51 is the most promiscuous integrin α subunit as it can form heterodimers with the β1 (CD29), β3 (CD61), β5, β6 and β8 subunits in various tissues. CD51/CD61 acts as an activation-independent receptor for platelet attachment and spreading on vitronectin and other RGD-containing proteins including matrix components. It also mediates leukocyte-endothelial cell adhesion via interaction with CD31.
Immunogen Cell suspension containing osteoclasts from osteoclastomas
Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Clonality Monoclonal
Concentration 0.1 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C
Applications Flow Cytometry – Quality tested 7,9,10
Immunohistochemistry-Frozen Sections – Reported in literature 1,5
Immunocytochemistry – Reported in literature 3
Immunoprecipitation – Reported in literature 2,3,5,9
ELISA – Reported in literature 8
Purification – Reported in literature 4,5
Depletion – Reported in literature 7
Blocking – Reported in literature 3,6
Adhesion – Reported in literature 3

RRID Number AB_2797043
Gene ID 3685 (Human)
103217487 (Green Monkey)
100008956 (Rabbit)
281875 (Bovine)
Gene ID Symbol ITGAV (Human)
ITGAV (Green Monkey)
ITGAV (Rabbit)
ITGAV (Bovine)
Gene ID Aliases CD51; MSK8; VNRA; VTNR
UniProt ID P06756 (Human)
P80746 (Bovine)
UniProt Name ITAV_HUMAN (Human)

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  1. 1. Horton MA, Lewis D, McNulty K, Pringle JA, Chambers TJ. Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens. Cancer Res. 1985;45:5563-9. (Immunogen, IHC-FS)
  2. 2. Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, et al. Transcriptional activation of integrin β6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest. 2005;115:339-47. (IP)
  3. 3. Adams JC, Watt FM. Expression of β1, β3, β4, and β5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes. J Cell Biol. 1991;115:829-41. (IP, ICC, Block, Adhesion)
  4. 4. Nesbitt S, Nesbit A, Helfrich M, Horton M. Biochemical characterization of human osteoclast integrins. Osteoclasts express αvβ3, α2β1, and αvβ1 integrins. J Biol Chem. 1993;268:16737-45. (Purification)
  5. 5. Davies J, Warwick J, Totty N, Philip R, Helfrich M, Horton M. The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor. J Cell Biol. 1989;109:1817-26. (IP, Purification, IHC-FS, African Green Monkey & Rabbit Reactivity)
  6. 6. Janes SM, Watt FM. Switch from αvβ5 to αvβ6 integrin expression protects squamous cell carcinomas from anoikis. J Cell Biol. 2004;166:419-31. (Block)
  7. 7. Pasqualini R, Bodorova J, Ye S, Hemler ME. A study of the structure, function and distribution of β5 integrins using novel anti-β5 monoclonal antibodies. J Cell Sci. 1993;105:101-11. (Depletion, FC)
  8. 8. Andreesen R, Brugger W, Scheibenbogen C, Kreutz M, Leser H, Rehm A, et al. Surface phenotype analysis of human monocyte to macrophage maturation. J Leukoc Biol. 1990;47:490-7. (ELISA)
  9. 9. Wong DA, Springer TA. Adhesion structure subpanels 7 and 8, β3, β4, β7 integrins and novel functional antigens: CD51, CD61, CD103, and CD104. In: Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, et al, editors. Leukocyte Typing V: White Cell Differentiation Antigens. Oxford: Oxford University Press; 1995. p. 1655-9. (IP, FC, Bovine Reactivity)
  10. 10. Gravelle S, Barnes R, Hawdon N, Shewchuk L, Eibl J, Lam JS, et al. Up-regulation of integrin expression in lung adenocarcinoma cells caused by bacterial infection: in vitro study. Innate Immun. 2010;16:14-26. (FC)
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