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Mouse Anti-Human FADD-HRP (1A11)

Cat. No.:
HRP Anti-Human FADD antibody for use in ELISA and western blot assays.
Size Price (USD) Quantity
1.0 mL $336.00
More Information
Clone 1A11
Isotype Mouse (BALB/c) IgG1κ
Isotype Control Mouse IgG1-HRP (15H6)
Specificity Human FADD
Alternative Names FAS-associated death domain protein, GIG3, MGC8528, MORT1
Description Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1β-converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation.
Immunogen Recombinant FADD
Conjugate HRP (Horseradish Peroxidase)
Buffer Formulation 50% Glycerol/50% Phosphate buffered saline, pH 7.4
Clonality Monoclonal
Concentration Lot specific
Volume 1.0 mL
Recommended Storage 2-8°C
Applications ELISA – Quality tested
Western Blot – Quality tested
Immunoprecipitation – Quality tested

RRID Number AB_2794560
Gene ID 8772 (Human)
Gene ID Symbol FADD (Human)
Gene ID Aliases GIG3; MORT1
UniProt ID Q13158 (Human)
UniProt Name FADD_HUMAN (Human)

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