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Rat Anti-Human Caspase-8-UNLB (SB125a)

Cat. No.:
Purified Anti-Human Caspase-8 antibody for use in western blot assays.
Size Price (USD) Quantity
0.1 mg $204.00
More Information
Clone SB125a
Isotype Rat (Sprague Dawley) IgMκ
Isotype Control Rat IgM-UNLB (NIP/M-2)
Specificity Human caspase-8
Alternative Names MACH, FLICE, Mch5
Description The caspases are a family of cysteine proteases that induce apoptosis in response to a variety of intra- and extracellular stimuli. These enzymes are synthesized as inactive precursors which become cleaved at aspartate-specific sites upon induction of apoptosis. Caspase-8 is a cytosolic protease that is capable of processing/activating all known caspases, indicating its presence early in the apoptotic cascade. It mediates cell death induction by receptors of the tumor necrosis factor (TNF) and nerve growth factor (NGF) family to eliminate injured cells and maintain leukocyte homeostasis. Moreover, studies have suggested it regulates Fas-induced cytotoxicity and may have a non-apoptotic role in macrophage differentiation.

The SB125a monoclonal antibody detects a band at ~55kD corresponding to the full length form of caspase-8.
Immunogen Purified native human caspase-8
Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Clonality Monoclonal
Concentration 1.0 mg/mL
Volume 0.1 mL
Recommended Storage 2-8°C
Applications Western Blot – Quality tested

RRID Number AB_2795202
Gene ID 841 (Human)
Gene ID Symbol CASP8 (Human)
Gene ID Aliases ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5
UniProt ID Q14790 (Human
UniProt Name CASP8_HUMAN (Human)

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