Mouse Anti-Human TRAIL-UNLB (SB91c)
Purified Anti-Human TRAIL antibody for use in ELISA assays.
|Mouse (BALB/c) IgG2bκ
|Mouse IgG2b-UNLB (A-1)
|CD253, Apo-2 ligand, Apo-2L, TNFSF10
| Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family of cytokines. This type II transmembrane protein is expressed by several cytotoxic immune cells, including natural killer cells and activated T cells, and is selective for tumorigenic and virally infected cells. TRAIL can bind to DR4 and DR5 receptors on target cells which facilitates recruitment of numerous signaling proteins to form a death-inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of caspase-8.
Numerous studies have identified TRAIL as a potent apoptotic factor in a variety of human cancer cell lines, but this cytokine does not appear to affect normal cell lines. Therefore, the selectivity and anti-tumorigenic properties of TRAIL make it an intriguing and potentially therapeutic agent in the treatment of cancer.
|Borate buffered saline, pH 8.2
| ELISA – Quality tested
| 8743 (Human)
|Gene ID Symbol
| TNFSF10 (Human)
|Gene ID Aliases
|APO2L; Apo-2L; CD253; TL2; TNLG6A; TRAIL
| P50591 (Human)
| TNF10_HUMAN (Human)