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Mouse Anti-Human FADD-SEPH (1A11)
Cat. No.:
10941-25
Agarose Anti-Human FADD antibody for use in immunoprecipitation assays.
$396.00
| Clone | 1A11 |
|---|---|
| Isotype | Mouse (BALB/c) IgG1κ |
| Isotype Control | 0102-25 |
| Specificity | Human FADD |
| Alternative Names | FAS-associated death domain protein, GIG3, MGC8528, MORT1 |
| Description | Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1β-converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation. |
| Immunogen | Recombinant FADD |
| Conjugate | SEPH (Agarose) |
| Buffer Formulation | Borate buffered saline, pH 8.2 |
| Clonality | Monoclonal |
| Concentration | Lot specific |
| Volume | 2.0 mL |
| Recommended Storage | 2-8°C |
| Trademark Information | Sepharose® is a registered trademark of Cytiva Bioprocess R&D AB |
| Applications | ELISA – Quality tested Western Blot – Quality tested Immunoprecipitation – Quality tested |
| RRID Number | AB_2794561 |
| Gene ID | 8772 (Human) |
| Gene ID Symbol | FADD (Human) |
| Gene ID Aliases | GIG3; MORT1 |
| UniProt ID | Q13158 (Human) |
| UniProt Name | FADD_HUMAN (Human) |
Documentation
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