Sign in / Register 
Mouse Anti-Human FADD-SEPH (1A11)
Cat. No.:
10941-25
Agarose Anti-Human FADD antibody for use in immunoprecipitation assays.
$396.00
| Clone | 1A11 |
|---|---|
| Isotype | Mouse (BALB/c) IgG1κ |
| Isotype Control | 0102-25 |
| Specificity | Human FADD |
| Alternative Names | FAS-associated death domain protein, GIG3, MGC8528, MORT1 |
| Description | Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1β-converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation. |
| Immunogen | Recombinant FADD |
| Conjugate | SEPH (Agarose) |
| Buffer Formulation | Borate buffered saline, pH 8.2 |
| Clonality | Monoclonal |
| Concentration | Lot specific |
| Volume | 2.0 mL |
| Recommended Storage | 2-8°C |
| Trademark Information | Sepharose® is a registered trademark of Cytiva Bioprocess R&D AB |
| Applications |
ELISA – Quality tested Western Blot – Quality tested Immunoprecipitation – Quality tested |
| RRID Number | AB_2794561 |
| Gene ID |
8772 (Human) |
| Gene ID Symbol |
FADD (Human) |
| Gene ID Aliases | GIG3; MORT1 |
| UniProt ID |
Q13158 (Human) |
| UniProt Name |
FADD_HUMAN (Human) |
Documentation
Certificate of Analysis Lookup
Enter the Catalog Number and Lot Number for the Certificate of Analysis you wish to view
Related Products
Check items to add to the cart or
