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Mouse Anti-Bcl-2-UNLB (10C4)

Cat. No.:
10065-01
Purified Anti-Bcl-2 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blot, and immunoprecipitation assays.
$180.00
Size Price (USD) Quantity
0.1 mg $180.00
More Information
Clone 10C4
Isotype Mouse IgG1κ
Isotype Control Mouse IgG1-UNLB (15H6)
Specificity Mouse/Rat Bcl-2
Alternative Names B cell leukemia 2
Description Bcl-2 is a 26 kDa member of the family of proteins involved in regulation of programmed cell death, or apoptosis. It is expressed in a variety of both normal and neoplastic tissues and appears to be membrane-bound since it is detectable in crude membrane and nuclear fractions, but not in the soluble fraction of cell lysates. Overexpression of Bcl-2 can prevent apoptosis, while formation of heterodimers with Bax, another Bcl-2-related protein, inhibits Bcl-2’s ability to promote cell survival.
Immunogen Murine Bcl-2 peptide (a.a. 61-76)
Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Clonality Monoclonal
Concentration 0.1 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C
Applications Western Blot – Quality tested 1-4
Immunoprecipitation – Reported in literature 3,4
Flow Cytometry – Reported in literature 5,6
Immunohistochemistry-Frozen Sections – Reported in literature 7
Immunohistochemistry-Paraffin Sections – Reported in literature 8
Immunocytochemistry – Reported in literature 3

RRID Number AB_2794109
Gene ID 12043 (Mouse)
24224 (Rat)
Gene ID Symbol Bcl2 (Mouse)
Bcl2 (Rat)
Gene ID Aliases AW986256; Bcl-2; C430015F12Rik; D630044D05Rik; D830018M01Rik
UniProt ID P10417 (Mouse)
P49950 (Rat)
UniProt Name BCL2_MOUSE (Mouse)
BCL2_RAT (Rat)

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  1. 1. Hsu Y, Youle RJ. Nonionic detergents induce dimerization among members of the Bcl-2 family. J Biol Chem. 1997;272:13829-34. (Immunogen, WB)
  2. 2. Hsu Y, Wolter KG, Youle RJ. Cytosol-to-membrane redistribution of Bax and Bcl-XL during apoptosis. Proc Natl Acad Sci USA. 1997;94:3668-72. (WB)
  3. 3. Conus S, Kaufmann T, Fellay I, Otter I, Rossé T, Borner C. Bcl-2 is a monomeric protein: prevention of homodimerization by structural constraints. EMBO J. 2000;19:1534-44. (WB, IP, ICC)
  4. 4. Gaudette BT, Iwakoshi NN, Boise LH. Bcl-xL protein protects from C/EBP homologous protein (CHOP)-dependent apoptosis during plasma cell differentiation. J Biol Chem. 2014;289:23629-40. (WB, IP)
  5. 5. McFarland HI, Puig M, Grajkowska LT, Tsuji K, Lee JP, Mason KP, et al. Regulatory T cells in γ irradiation-induced immune suppression. PLoS One. 2012;7(6):e39092. (FC)
  6. 6. Wang X, Szymczak-Workman AL, Gravano DM, Workman CJ, Green DR, Vignali DA. Preferential control of induced regulatory T cell homeostasis via a Bim/Bcl-2 axis. Cell Death Dis. 2012;3:e270. (FC)
  7. 7. Yamanaka T, Helgeland L, Farstad IN, Fukushima H, Midtvedt T, Brandtzaeg P. Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patches. J Immunol. 2003;170:816-22. (IHC-FS)
  8. 8. Saatli B, Kizildag S, Posaci C, Dogan E, Koyuncuoglu M, Ulukus EC, et al. Long-term effects of GnRH agonist, GnRH antagonist, and estrogen plus progesterone treatment on apoptosis related genes in rat ovary. Fertil Steril. 2009;91:2006-11. (IHC-PS)
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