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Rat Anti-Mouse CD16/32-FITC (93)

Cat. No.:
1630-02
FITC Anti-Mouse CD16/32 antibody for use in flow cytometry and immunohistochemistry assays.
$235.00
Size Price (USD) Quantity
0.5 mg $235.00
More Information
Clone 93
Isotype Rat IgG2aλ
Isotype Control Rat IgG2a-FITC (KLH/G2a-1-1)
Specificity Mouse CD16/32
Alternative Names FcRγII, FcRγIII, Fc gamma II receptor, Fc gamma III receptor, FcFR2, IGFR2, FcGR3, IGFR3, Fc receptor block
Description The lymphocyte Fcγ receptors recognize the Fc portion of IgG, presented either as immune complexes or as free antibody. The different classes of receptors are distinct because of varying size, tissue distribution and affinity for IgGs. The Fc type II receptor is expressed on a wide variety of cells including B cells, hematopoietic cells, monocyte/macrophages, neutrophils, platelets, Langerhans cells, eosinophils, basophils, trophoblasts, and endothelial cells of the placenta. The Fcγ type III receptors are higher affinity than the type II and are expressed on macrophages, NK cells and neutrophils. Both types of receptors can be expressed on the same cell and in varying ratios. The receptors are constitutively expressed, although cytokines and lymphokines can modulate their expression. Besides identifying FcγR+ cells, monoclonal antibodies to the FcγII/III receptor have been used to block Fc receptor binding of IgG, Fc-mediated signal transduction and effector functions, clearance of immune complexes and to attenuate infection by organisms dependent on FcγR for parasitic invasion. The monoclonal antibody 93 recognizes a conformational epitope formed by FcγII and FcγIII receptors.
Immunogen VH81X Tg B cells and T220 stromal cell line
Conjugate FITC (Fluorescein)
Buffer Formulation Phosphate buffered saline containing < 0.1% sodium azide
Clonality Monoclonal
Concentration 0.5 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C; Avoid exposure to light
Applications Flow Cytometry – Quality tested 2,5
Immunohistochemistry-Frozen Sections – Reported in literature 6
Immunoprecipitation – Reported in literature 6
Blocking – Reported in literature 1-4

RRID Number AB_2795055
Gene ID 14131 (Mouse)
14130 (Mouse)
Gene ID Symbol Fcgr3 (Mouse)
Fcgr2b (Mouse)
Gene ID Aliases CD16; CD32; Fcgr2; Fcr-2; Fcr-3; Ly-17; LyM-1; Lym-1; fcRII; FcgRII; Fcgr2a; Ly-m20; AI528646; Fc[g]RII; F630109E10Rik
UniProt ID P08508 (Mouse)
P08101 (Mouse)
UniProt Name FCGR3_MOUSE (Mouse)
FCGR2_MOUSE (Mouse)

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  1. 1. Rainczuk A, Scorza T, Smooker PM, Spithill TW. Induction of specific T-cell responses, opsonizing antibodies, and protection against Plasmodium chabaudi adami infection in mice vaccinated with genomic expression libraries expressed in targeted and secretory DNA vectors. Infect Immun. 2003;71:4506-15. (Block)
  2. 2. Petersen LK, Xue L, Wannemuehler MJ, Rajan K, Narasimhan B. The simultaneous effect of polymer chemistry and device geometry on the in vitro activation of murine dendritic cells. Biomaterials. 2009;30:5131-42. (Block, FC)
  3. 3. Safari D, Dekker HA, Rijkers G, Snippe H. Codelivery of adjuvants at the primary immunization site is essential for evoking a robust immune response to neoglycoconjugates. Vaccine. 2011;29:849-54. (Block)
  4. 4. Petersen LK, Ramer-Tait AE, Broderick SR, Kong C, Ulery BD, Rajan K, et al. Activation of innate immune responses in a pathogen-mimicking manner by amphiphilic polyanhydride nanoparticle adjuvants. Biomaterials. 2011;32:6815-22. (Block)
  5. 5. He W, Hu Z, Liu F, Feng X, Zou P. In vitro co-stimulation of anti-tumor activity by soluble B7 molecules. Acta Biochim Pol. 2006;53:807-13. (FC)
  6. 6. Personal communication (IHC-FS, IP)
See All References