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Rat Anti-Mouse CD117-UNLB (3C1)

Cat. No.:
1885-01
Purified Anti-Mouse CD117 antibody for use in flow cytometry and immunoprecipitation assays.
$192.00
Size Price (USD) Quantity
0.5 mg $192.00
More Information
Clone 3C1
Isotype Rat (Wistar) IgG2bκ
Isotype Control Rat IgG2b-UNLB (KLH/G2b-1-2)
Specificity Mouse CD117
Alternative Names c-Kit, mast cell growth factor, stem cell factor, steel factor, SCF
Description The CD117 (c-Kit) antigen is the cell-surface receptor for stem cell factor (SCF). Together these molecules constitute a ligand/receptor pair which functions to maintain normal hematopoiesis in the adult. Signaling through SCF/c-Kit has an important role in stimulating myeloid and erythroid production of primitive hematopoietic progenitor cells. A variety of cytokines act synergistically with SCF to stimulate proliferation and differentiation of bone marrow progenitor cells. For example, SCF plus IL-7 can stimulate the combined myeloid and B cell differentiation of uncommitted hematopoietic progenitor cells. SCF/c-Kit also participates in erythropoiesis in both the bone marrow and spleen. Loss-of-function mutations for SCF/c-Kit lead to a variety of pleiotropic developmental defects while gain-of-function mutations can lead to constitutive activation of the kit receptor and links to cancer. Examples of the former are mast cell deficiency and severe macrocytic anemia while the latter mutation has been identified in mastocytomas.
Immunogen Mouse IL-3-dependent bone marrow mast cells
Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Clonality Monoclonal
Concentration 0.5 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C
Applications Flow Cytometry – Quality tested 1
Immunoprecipitation – Reported in literature 1

RRID Number AB_2795436
Gene ID 16590 (Mouse)
Gene ID Symbol Kit (Mouse)
Gene ID Aliases Bs; CD117; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W; c-KIT
UniProt ID P05532 (Mouse)
UniProt Name KIT_MOUSE (Mouse)

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  1. 1. Ikuta K, Weissman IL. Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc Natl Acad Sci USA. 1992;89:1502-6. (Immunogen, FC, IP)