Ensuring timely antibody supply during the COVID-19 pandemic - contact us for solutions

Rat Anti-Mouse CD71-LE/AF (RI7217)

Cat. No:
1720-14
Low Endotoxin/Azide Free Anti-Mouse CD71 antibody for use in flow cytometry, immunocytochemistry, western blot, immunoprecipitation, blocking, separation, and drug delivery assays.
$265.00
Size Price (USD) Quantity
0.5 mg $265.00
More Information
Clone RI7217
Isotype Rat (BDIX) IgG2aκ
Isotype Control Rat IgG2a-LE/AF (KLH/G2a-1-1)
Specificity Mouse CD71
Alternative Names T9, transferrin receptor, TfR
Description CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the transferrin receptor. It is essential for the growth of normal and neoplastic cells. It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens presumably reflecting the iron dependence of proliferation. Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron which is essential for many metabolic pathways through the binding and endocytosis of transferrin, the major iron-carrying protein. It may also be involved in signal transduction via its association with the T cell receptor ζ chain. The monoclonal antibody RI7217 inhibits cell proliferation in vitro.
Immunogen DMSO induced Friend erythroleukemia 745.6
Conjugate LE/AF (Low Endotoxin/Azide Free)
Buffer Formulation Phosphate buffered saline, pH 7.4
Clonality Monoclonal
Concentration 0.5 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C; Handle under aseptic conditions
Applications Flow Cytometry – Quality tested 1,2,4,5
Immunocytochemistry – Reported in literature 5
Immunoprecipitation – Reported in literature 2
Western Blot – Reported in literature 9
Blocking – Reported in literature 2,3
Separation – Reported in literature 6
Drug Delivery – Reported in literature 7,8

RRID Number AB_2795194
Gene ID 22042 (Mouse)
Gene ID Symbol Tfrc (Mouse)
Gene ID Aliases TR; TFR; p90; CD71; TFR1; Trfr; Mtvr1; 2610028K12Rik; E430033M20Rik
UniProt ID Q62351 (Mouse)
UniProt Name TFR1_MOUSE (Mouse)

Certificate of Analysis Lookup

Enter the Catalog Number and Lot Number for the Certificate of Analysis you wish to view


Need help with this product?
or call 800.722.2255
  1. 1. Lesley J, Hyman R, Schulte R, Trotter J. Expression of transferrin receptor on murine hematopoietic progenitors. Cell Immunol. 1984;83:14-25. (Immunogen, FC)
  2. 2. Lesley JF, Schulte RJ. Inhibition of cell growth by monoclonal anti-transferrin receptor antibodies. Mol Cell Biol. 1985;5:1814-21. (FC, IP, Block)
  3. 3. Kemp JD, Thorson JA, Gomez F, Snith KM, Cowdery JS, Ballas ZK. Inhibition of lymphocyte activation with anti-transferrin receptor Mabs: A comparison of three reagents and further studies of their range of effects and mechanism of action. Cell Immunol. 1989;122:218-30. (Block)
  4. 4. van der Weyden L, Arends MJ, Rust AG, Poulogiannis G, McIntyre RE, Adams DJ. Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1. Mol Cancer. 2012;11:29. (FC)
  5. 5. Wang J, Wagner-Britz L, Bogdanova A, Ruppenthal S, Wiesen K, Kaiser E, et al. Morphologically homogeneous red blood cells present a heterogeneous response to hormonal stimulation. PloS One. 2013;8(6):e67697. (ICC, FC)
  6. 6. Romero JR, Suzuka SM, Nagel RL, Fabry ME. Expression of HbC and HbS, but not HbA, results in activation of K-Cl cotransport activity in transgenic mouse red cells. Blood. 2004;103:2384-90. (Sep)
  7. 7. Inoue S, Patil R, Portilla-Arias J, Ding H, Konda B, Espinoza A, et al. Nanobiopolymer for direct targeting and inhibition of EGFR expression in triple negative breast cancer. PLoS One. 2012;7(2):e31070. (Drug Delivery)
  8. 8. Inoue S, Ding H, Portilla-Arias J, Hu J, Konda B, Fujita M, et al. Polymalic acid-based nanobiopolymer provides efficient systemic breast cancer treatment by inhibiting both HER2/neu receptor synthesis and activity. Cancer Res. 2011;71:1454-64. (Drug Delivery)
  9. 9. Fiani ML, Beitz J, Turvy D, Blum JS, Stahl PD. Regulation of mannose receptor synthesis and turnover in mouse J774 macrophages. J Leukoc Biol. 1998;64:85-91. (WB)
See All References