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Rat Anti-Mouse NKG2-A/C/E-UNLB (20d5)

Cat. No.:
Purified Anti-Mouse NKG2-A/C/E antibody for use in flow cytometry and blocking assays.
Size Price (USD) Quantity
0.5 mg $237.00
More Information
Clone 20d5
Isotype Rat (Lewis) IgG2aκ
Isotype Control Rat IgG2a-UNLB (KLH/G2a-1-1)
Specificity Mouse NKG2-A/C/E
Alternative Names NKG2A, NKG2C, NKG2E
Description The monoclonal antibody 20d5 reacts with an epitope common to the NKG2A, NKG2C and NKG2E isoforms of the NKG2 heterodimer, a member of the c-type lectin family of inhibitory receptors. Mouse NKG2 is a natural killer (NK) cell receptor for the non-classical MHC class I molecule Qa-1b. NKG2 is expressed on NK cells, lymphokine-activated killer (LAK) T cells, and some CD8+ memory T cells. Two-color immunofluorescent staining with the 20d5 antibody reveals two distinct NKG2+ phenotypes within the NK1.1+CD3- spleen cell population: NKG2hi (50%) and NKG2low (50%). With the exception of DBA/2J mice, NKG2 is expressed on NK1.1+ cells from all mouse strains tested (C57BL/6, BALB/c, 129/J, C3H.SW, AKR/J, SJL).
Immunogen CHO cells transfected with B6 allele of NKG2A gene
Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Clonality Monoclonal
Concentration 0.5 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C
Applications Flow Cytometry – Quality tested 1-3
Blocking – Reported in literature 1

RRID Number AB_2795340
Gene ID 16641 (Mouse)
16642 (Mouse)
58179 (Mouse)
Gene ID Symbol Klrc1 (Mouse)
Klrc2 (Mouse)
Klrc3 (Mouse)
Gene ID Aliases NKG2A; NKG2B; CD159a; NKG2C; Klrc2; Nkg2e

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  1. 1. Vance RE, Jamieson AM, Raulet DH. Recognition of the class Ib molecule Qa-1b by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells. J Exp Med. 1999;190:1801-12. (Immunogen, FC, Block)
  2. 2. Fraser KP, Gays F, Robinson JH, van Beneden K, Leclercq G, Vance RE, et al. NK cells developing in vitro from fetal mouse progenitors express at least one member of the Ly49 family that is acquired in a time-dependent and stochastic manner independently of CD94 and NKG2. Eur J Immunol. 2002;32:686-78. (FC)
  3. 3. Lian RH, Maeda M, Lohwasser S, Delcommenne M, Nakano T, Vance RE, et al. Orderly and nonstochastic acquisition of CD94/NKG2 receptors by developing NK cells derived from embryonic stem cells in vitro. J Immunol. 2002;168:4980-7. (FC)