Mouse Anti-Cytokeratin 19-FITC
Cat. No.
10090-02
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Size
0.1 mg
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Price (USD)
$240.00
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| Clone |
SB39g
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| Isotype |
Mouse (BALB/c) IgG2aκ
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| Isotype Control |
Mouse IgG2a-FITC
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| Immunogen |
Recombinant C-terminal cytokeratin 19
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| Specificity |
Cytokeratin 19
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| Alternalte Name(s) |
CK 19, keratin 19
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| Description |
Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1-8). The two keratin types share only 30% sequence homology. Keratins demonstrate tissue- and differentiation-specific expression profiles. Cytokeratin 19 is the smallest human keratin. It is found in many simple and some non-keratinizing stratified squamous epithelia and is often co-expressed with keratin 7. Cytokeratin 19 has been implicated as a marker for stem cells in some tissues such as hair follicles in the skin. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. The degree of cytokeratin 19 positivity in breast cancer distinguishes malignant from benign tumors. Cytokeratin 19 is also associated with malignant transformation in esophageal and pancreatic cancers.
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| Format/Conjugate |
FITC (Fluorescein)
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| Buffer Formulation |
Phosphate buffered saline containing < 0.1% sodium azide
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| Concentration |
0.5 mg/mL
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| Volume |
0.2 mL
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| Storage & Handling |
2-8°C; Avoid exposure to light
Please refer to product specific SDS
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| Applications |
Applications for relevant formats of this clone include - ELISA – Quality tested
FLISA – Quality tested
Western Blot – Quality tested
Immunohistochemistry-Paraffin Sections 2
Immunocytochemistry 2
Flow Cytometry – Reported in literature 1
Immunoprecipitation 3
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| Recommended Dilutions |
Please refer to product specific Technical Bulletin
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| RRID |
AB_2794118
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| Gene ID |
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| Gene Symbol |
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| Gene Aliases |
K19; CK19; K1CS
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| Uniprot ID |
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| Uniprot Name |
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Human pancreatic carcinoma cell line MIA PaCa-2 was stained with Mouse Anti-Cytokeratin 19-FITC (SB Cat. No. 10090-02) followed by DAPI.
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FLISA plate was coated with recombinant cytokeratin 19 and purified/unlabeled Rat IgMκ. Cytokeratin and purified immunoglobulin were detected with serially diluted Mouse Anti-Cytokeratin 19-FITC (SB Cat. No. 10090-02).
Human pancreatic carcinoma cell line MIA PaCa-2 was stained with Mouse Anti-Cytokeratin 19-FITC (SB Cat. No. 10090-02) followed by DAPI.
FLISA plate was coated with recombinant cytokeratin 19 and purified/unlabeled Rat IgMκ. Cytokeratin and purified immunoglobulin were detected with serially diluted Mouse Anti-Cytokeratin 19-FITC (SB Cat. No. 10090-02).
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References
| 1. | Berglin L, Björkström NK, Bergquist A. Primary sclerosing cholangitis is associated with autoreactive IgA antibodies against biliary epithelial cells. Scand J Gastroenterol. 2013;48:719-28. (FC) | | 2. | SouthernBiotech published data (IHC-PS, ICC) | | 3. | SouthernBiotech unpublished data (IP) |
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