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Mouse Anti-Cytokeratin 19-FITC

Cat. No.
10090-02

Size
0.1 mg

Price (USD)
$240.00

Qty	Add to Cart

Technical Bulletin Certificate of
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Clone	SB39g
Isotype	Mouse (BALB/c) IgG_2aκ
Isotype Control	Mouse IgG_2a-FITC
Immunogen	Recombinant C-terminal cytokeratin 19
Specificity	Cytokeratin 19
Alternalte Name(s)	CK 19, keratin 19
Description	Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1-8). The two keratin types share only 30% sequence homology. Keratins demonstrate tissue- and differentiation-specific expression profiles. Cytokeratin 19 is the smallest human keratin. It is found in many simple and some non-keratinizing stratified squamous epithelia and is often co-expressed with keratin 7. Cytokeratin 19 has been implicated as a marker for stem cells in some tissues such as hair follicles in the skin. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. The degree of cytokeratin 19 positivity in breast cancer distinguishes malignant from benign tumors. Cytokeratin 19 is also associated with malignant transformation in esophageal and pancreatic cancers.
Format/Conjugate	FITC (Fluorescein)
Buffer Formulation	Phosphate buffered saline containing 0.1% sodium azide
Concentration	0.5 mg/mL
Volume	0.2 mL
Storage & Handling	2-8°C; Avoid exposure to light Please refer to product specific SDS
Applications	Applications for relevant formats of this clone include - ELISA – Quality tested FLISA – Quality tested Western Blot – Quality tested Immunohistochemistry-Paraffin Sections ² Immunocytochemistry ² Flow Cytometry – Reported in literature ¹ Immunoprecipitation ³
Recommended Dilutions	Please refer to product specific Technical Bulletin

Human pancreatic carcinoma cell line MIA PaCa-2 was stained with Mouse Anti-Cytokeratin 19-FITC (SB Cat. No. 10090-02) followed by DAPI.

Human pancreatic carcinoma cell line MIA PaCa-2 was stained with Mouse Anti-Cytokeratin 19-FITC (SB Cat. No. 10090-02) followed by DAPI.

References

1.	Berglin L, Björkström NK, Bergquist A. Primary sclerosing cholangitis is associated with autoreactive IgA antibodies against biliary epithelial cells. Scand J Gastroenterol. 2013;48:719-28. (FC)
2.	SouthernBiotech published data (IHC-PS, ICC)
3.	SouthernBiotech unpublished data (IP)

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