Mouse Anti-Human GFAP-UNLB

Cat. No.
12070-01  
Size
0.5 mg  
Price (USD)
$185.00 
Clone SB61a
Isotype Mouse (BALB/c) IgG1κ
Isotype Control Mouse IgG1-UNLB
Immunogen Recombinant human GFAP
Specificity Human GFAP
Alternalte Name(s) Glial fibrillary acidic protein, intermediate filament protein
Description Glial fibrillary acid protein (GFAP) is a member of the type III intermediate filament family of proteins. GFAP is heavily expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. It is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and functions of the cell’s cytoskeleton. GFAP is thought to help to maintain astrocyte mechanical strength, as well as the shape of cell; however, its precise function remains poorly understood. In adults, GFAP levels increase in response to the proliferation of astrocytes associated with Alzheimer’s disease, epilepsy, and multiple sclerosis. Antibodies specific for GFAP are useful as markers of astrocytic cells and neural stem cells as well as for distinguishing neoplasms of astrocytic origin from other neoplasms in the central nervous system.
Format/Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Concentration 0.5 mg/mL
Volume 1.0 mL
Storage & Handling 2-8°C
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
Immunocytochemistry – Quality tested
ELISA-Capture – Quality tested

Note – May be paired with the biotinylated clone SB61b (SB Cat. No. 12075-08) in a sandwich ELISA
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2794710
Gene ID
2670 (Human)
Gene Symbol
GFAP (Human)
Gene Aliases ALXDRD
Uniprot ID
P14136 (Human)
Uniprot Name
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