Mouse Anti-Human GFAP-BIOT

Cat. No.
12075-08  
Size
0.5 mg   		Price (USD)
$210.00 
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Technical Bulletin Certificate of
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Clone SB61b
Isotype Mouse (BALB/c) IgG2bκ
Isotype Control Mouse IgG2b-BIOT
Immunogen Recombinant human GFAP
Specificity Human/Mouse GFAP
Alternalte Name(s) Glial fibrillary acidic protein, intermediate filament protein
Description Glial fibrillary acid protein (GFAP) is a member of the type III intermediate filament family of proteins. GFAP is heavily expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. It is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and functions of the cell’s cytoskeleton. GFAP is thought to help to maintain astrocyte mechanical strength, as well as the shape of cell; however, its precise function remains poorly understood. In adults, GFAP levels increase in response to the proliferation of astrocytes associated with Alzheimer’s disease, epilepsy, and multiple sclerosis. Antibodies specific for GFAP are useful as markers of astrocytic cells and neural stem cells as well as for distinguishing neoplasms of astrocytic origin from other neoplasms in the central nervous system.
Format/Conjugate BIOT (Biotin)
Buffer Formulation Phosphate buffered saline containing < 0.1% sodium azide
Concentration 0.5 mg/mL
Volume 1.0 mL
Storage & Handling 2-8°C
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
Immunocytochemistry – Quality tested
Immunohistochemistry-Frozen Sections – Reported in literature 1
Western Blot 2
ELISA-Detection 2

Note – May be paired with the purified clone SB61a (SB Cat. No. 12070-01) in a sandwich ELISA
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2794713
Gene ID
2670 (Human)
14580 (Mouse)
Gene Symbol
GFAP (Human)
Gfap (Mouse)
Gene Aliases ALXDRD; AI836096
Uniprot ID
P14136 (Human)
P03995 (Mouse)
Uniprot Name
GFAP_HUMAN 
GFAP_MOUSE
  • Mouse Anti-Human GFAP-CY3
    Human astrocytoma cell line CCF-STTG1 was stained with Mouse Anti-Human GFAP-CY3 (SB Cat. No. 12075-12) and DAPI.

Human astrocytoma cell line CCF-STTG1 was stained with Mouse Anti-Human GFAP-CY3 (SB Cat. No. 12075-12) and DAPI.
 
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References
1. Pons-Espinal M, de Lagran MM, Dierssen M. Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A. Neurobiol Dis. 2013;60:18-31. (IHC-FS, Mouse Reactivity)
2. SouthernBiotech unpublished data (WB, ELISA)