Mouse Anti-Human IL-33-UNLB

Cat. No.
15710-01  
Size
0.5 mg  
Price (USD)
$270.00 
Clone SB127j
Isotype Mouse (BALB/c) IgG2aκ
Isotype Control Mouse IgG2a-UNLB
Immunogen E. coli-expressed human IL-33
Specificity Human IL-33
Alternalte Name(s) Interleukin-33, IL-1F11, NF-HEV
Description Interleukin-33 (IL-33), also known as NF-HEV, is a 30 kDa protein and a member of the IL-1 family. This pro-inflammatory cytokine is produced by a variety of cells but is primarily expressed by endothelial and smooth muscle cells in the vasculature and airways. IL-33 binds to the ST2 receptor on target cells which results in the activation of multiple signaling pathways including NF-κB and MAP kinases. Studies have shown that IL-33 promotes T helper type 2 (Th2) cell-mediated immune responses and upregulates production of Th2 associated cytokines including IL-4, IL-5, and IL-13. In vivo administration of this cytokine in mice results in eosinophilia and splenomegaly as well as induced severe pathological changes in the lungs, gastrointestinal tract, and other mucosal organs.
Format/Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Concentration 0.5 mg/mL
Volume 1.0 mL
Storage & Handling 2-8°C
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
ELISA – Quality tested

Note – May be paired with the biotinylated clone SB127c (SB Cat. No. 15700-08) in a sandwich ELISA
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2794945
Gene ID
90865 (Human)
Gene Symbol
IL33 (Human)
Gene Aliases C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV
Uniprot ID
O95760 (Human)
Uniprot Name
  • Standard curve generated with Mouse Anti-Human IL-33-UNLB (SB Cat. No. 15710-01; Clone SB127j) and Mouse Anti-Human IL-33-BIOT (SB Cat. No. 15700-08; Clone SB127c) followed by Streptavidin-HRP (SB Cat. No. 7100-05)

Standard curve generated with Mouse Anti-Human IL-33-UNLB (SB Cat. No. 15710-01; Clone SB127j) and Mouse Anti-Human IL-33-BIOT (SB Cat. No. 15700-08; Clone SB127c) followed by Streptavidin-HRP (SB Cat. No. 7100-05)
 
Related Products (8)