Mouse Anti-Human IL-33-UNLB
Cat. No.
15710-01
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Size
0.5 mg
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Price (USD)
$270.00
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| Clone |
SB127j
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| Isotype |
Mouse (BALB/c) IgG2aκ
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| Isotype Control |
Mouse IgG2a-UNLB
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| Immunogen |
E. coli-expressed human IL-33
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| Specificity |
Human IL-33
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| Alternalte Name(s) |
Interleukin-33, IL-1F11, NF-HEV
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| Description |
Interleukin-33 (IL-33), also known as NF-HEV, is a 30 kDa protein and a member of the IL-1 family. This pro-inflammatory cytokine is produced by a variety of cells but is primarily expressed by endothelial and smooth muscle cells in the vasculature and airways. IL-33 binds to the ST2 receptor on target cells which results in the activation of multiple signaling pathways including NF-κB and MAP kinases. Studies have shown that IL-33 promotes T helper type 2 (Th2) cell-mediated immune responses and upregulates production of Th2 associated cytokines including IL-4, IL-5, and IL-13. In vivo administration of this cytokine in mice results in eosinophilia and splenomegaly as well as induced severe pathological changes in the lungs, gastrointestinal tract, and other mucosal organs.
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| Format/Conjugate |
UNLB (Unconjugated)
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| Buffer Formulation |
Borate buffered saline, pH 8.2
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| Concentration |
0.5 mg/mL
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| Volume |
1.0 mL
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| Storage & Handling |
2-8°C
Please refer to product specific SDS
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| Applications |
Applications for relevant formats of this clone include - ELISA – Quality tested
Note – May be paired with the biotinylated clone SB127c (SB Cat. No. 15700-08) in a sandwich ELISA
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| Recommended Dilutions |
Please refer to product specific Technical Bulletin
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| RRID |
AB_2794945
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| Gene ID |
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| Gene Symbol |
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| Gene Aliases |
C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV
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| Uniprot ID |
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| Uniprot Name |
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-
Standard curve generated with Mouse Anti-Human IL-33-UNLB (SB Cat. No. 15710-01; Clone SB127j) and Mouse Anti-Human IL-33-BIOT (SB Cat. No. 15700-08; Clone SB127c) followed by Streptavidin-HRP (SB Cat. No. 7100-05)
Standard curve generated with Mouse Anti-Human IL-33-UNLB (SB Cat. No. 15710-01; Clone SB127j) and Mouse Anti-Human IL-33-BIOT (SB Cat. No. 15700-08; Clone SB127c) followed by Streptavidin-HRP (SB Cat. No. 7100-05)
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