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Rat Anti-Mouse CD38-APC (90)
Cat. No.:
1640-11
APC Anti-Mouse CD38 antibody for use in flow cytometry assays.
$301.00
| Clone | 90 |
|---|---|
| Isotype | Rat IgG2aκ |
| Isotype Control | Rat IgG2a-APC (KLH/G2a-1-1) |
| Specificity | Mouse CD38 |
| Alternative Names | T10, ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase |
| Description | Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR), and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral B-lineage cells and at low density on germinal center B cells from unimmunized mice. It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCRαβ+, CD4-, CD8-. Murine CD38 is also expressed by all Mac-1+ macrophages in the peritoneal cavities of unimmunized mice but not by unstimulated bone-marrow-derived macrophages. Monoclonal antibodies to CD38 have been shown to induce B and T cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis. |
| Immunogen | Mouse bone marrow pre-B cells |
| Conjugate | APC (Allophycocyanin) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide and a stabilizer |
| Clonality | Monoclonal |
| Concentration | 0.1 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C; Avoid exposure to light; Do not freeze |
| Applications | Flow Cytometry – Quality tested 1 Immunohistochemistry-Frozen Sections – Reported in literature 1 Immunoprecipitation – Reported in literature 1 Stimulation – Reported in literature 2 |
| RRID Number | AB_2795077 |
| Gene ID | 12494 (Mouse) |
| Gene ID Symbol | Cd38 (Mouse) |
| Gene ID Aliases | I-19; ADPRC 1; Cd38-rs1 |
| UniProt ID | P56528 (Mouse |
| UniProt Name | CD38_MOUSE (Mouse) |
Documentation
Certificate of Analysis Lookup
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- 1. Oliver AM, Martin F, Kearney JF. Mouse CD38 is down-regulated on germinal center B cells and mature plasma cells. J Immunol. 1997;158:1108-15. (Immunogen, IP, IHC-FS, FC)
- 2. Etich J, Bergmeier V, Frie C, Kreft S, Bengestrate L, Eming S, et al. PECAM1+/Sca1+/CD38+ vascular cells transform into myofibroblast-like cells in skin wound repair. PLoS One. 2013;8(1):e53262. (Stim)
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