Rat Anti-Mouse CD24-LE/AF

Cat. No.
1815-14  
Size
0.5 mg   		Price (USD)
$300.00 
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Clone 30-F1
Isotype Rat (LOU/Ws1/M) IgG2cκ
Isotype Control Rat IgG2c-LE/AF
Immunogen Mouse thymus or spleen
Specificity Mouse CD24
Alternalte Name(s) Heat stable antigen, HSA
Description CD24 is expressed in B cells until their terminal differentiation into plasma cells. It has been used widely as a marker to fractionate different B-lineage differentiation stages. CD24 has been found on a variety of other hematopoietic and neural cell types and is now classified as a costimulatory molecule. The CD24 molecule, also known as HSA, is composed mostly of carbohydrate with a protein core of only 31-35 amino acids in the human and 27 amino acids in the mouse. CD24 is now included in the large group of phosphatidylinositol-anchored membrane proteins. Studies with purified CD24 applied to latex beads have demonstrated a self-binding property suggesting that the molecule is capable of promoting homotypic aggregation, binding, and cell adhesion. This is supported by earlier observations of the blockade of B cell lymphoblast aggregation with an anti-CD24 monoclonal antibody. Recent studies of murine CD24 have assigned a role for CD24 as a ligand for P-selectin, a calcium-dependent lectin.
Format/Conjugate LE/AF (Low Endotoxin/Azide Free)
Buffer Formulation Phosphate buffered saline, pH 7.4
Concentration 0.5 mg/mL
Volume 1.0 mL
Storage & Handling -20°C
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
Flow Cytometry – Quality tested 1-4
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2795392
Gene ID
12484 (Mouse)
Gene Symbol
Cd24a (Mouse)
Gene Aliases HSA; Cd24; Ly-52; nectadrin
Uniprot ID
P24807 (Mouse)
Uniprot Name
CD24_MOUSE 
  • Rat Anti-Mouse CD24-APC
    C57BL/6 mouse splenocytes were stained with Rat Anti-Mouse CD24-APC (SB Cat. No. 1815-11) and Rat Anti-Mouse CD19-FITC (SB Cat. No. 1575-02).

C57BL/6 mouse splenocytes were stained with Rat Anti-Mouse CD24-APC (SB Cat. No. 1815-11) and Rat Anti-Mouse CD19-FITC (SB Cat. No. 1575-02).
 
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References
1. Ledbetter JA, Herzenberg LA. Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. Immunol Rev. 1979;47:63-90. (Immunogen, FC)
2. Palmer VL, Kassmeier MD, Willcockson J, Akhter MP, Cullen DM, Swanson PC. N-acetylcysteine increases the frequency of bone marrow pro-B/pre-B cells, but does not reverse cigarette smoking-induced loss of this subset. PLoS One. 2011;6:e24804. (FC)
3. Hassaballa AE, Palmer VL, Anderson DK, Kassmeier MD, Nganga VK, Parks KW, et al. Accumulation of B1-like B cells in transgenic mice over-expressing catalytically inactive RAG1 in the periphery. Immunology. 2011;134:469-86. (FC)
4. Kassmeier MD, Mondal K, Palmer VL, Ravel P, Kumar S, Perry GA, et al. VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity. EMBO J. 2012;31:945-58. (FC)