Mouse Anti-Human CD56-PE/CY5.5

Cat. No.
9456-16  
Size
100 tests  
Price (USD)
$260.00 
Clone MEM 188
Isotype Mouse IgG2aκ
Isotype Control Mouse IgG2a-PE/CY5.5
Immunogen Acute myelogenous leukemia cell line KG-1
Specificity Human/Porcine CD56
Alternalte Name(s) NCAM, neural cell adhesion molecule, Leu-19, NKH1
Description CD56, an isoform of the neural cell adhesion molecule (NCAM), is a heavily glycosylated type I transmembrane protein. On human hematopoietic cells its expression is restricted to NK cells and a subpopulation of T lymphocytes (known as large granular lymphocytes) which demonstrate natural killer activity. While it is clear that NCAM plays a role in homotypic adhesion of neuronal cells, the significance of CD56 expression on NK cells is not clear and remains controversial.
Format/Conjugate PE/CY5.5 (R-phycoerythrin/Cyanine 5.5)
Buffer Formulation Phosphate buffered saline containing 0.1% sodium azide and a stabilizer
Volume 1.0 mL
Storage & Handling 2-8°C; Avoid exposure to light; Do not freeze
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
Flow Cytometry – Quality tested 1,6-9
Immunohistochemistry-Frozen Sections – Reported in literature 1
Immunocytochemistry – Reported in literature 2
Separation – Reported in literature 3,4
Blocking – Reported in literature 5
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2796808
  • Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD56-PE/CY5.5 (SB Cat. No. 9456-16) and Mouse Anti-Human CD19-PE (SB Cat. No. 9340-09).

Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD56-PE/CY5.5 (SB Cat. No. 9456-16) and Mouse Anti-Human CD19-PE (SB Cat. No. 9340-09).
 
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References
1. Zahn S, Rehkämper C, Ferring-Schmitt S, Bieber T, Tüting T, Wenzel J. Interferon-α stimulates TRAIL expression in human keratinocytes and peripheral blood mononuclear cells: implications for the pathogenesis of cutaneous lupus erythematosus. Br J Dermatol. 2011;165:1118-23. (IHC-FS, FC)
2. Hanabuchi S, Watanabe N, Wang Y, Wang Y, Ito T, Shaw J, et al. Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL). Blood. 2006;107:3617-23. (ICC)
3. Berney SM, Schaan T, Alexander JS, Peterman G, Hoffman PA, Wolf RE, et al. ICAM-3 (CD50) cross-linking augments signaling in CD3-activated peripheral human T lymphocytes. J Leukoc Biol. 1999;65:867-74. (Sep)
4. Liao, J, Huang M, Fast K, Gundling K, Yadav M, van Brocklyn JR, et al. Immunosuppressive human anti-lymphocyte autoantibodies specific for the type 1 sphingosine 1-phosphate receptor. FASEB J. 2009;23:1786-96. (Sep)
5. Kos FJ, Chin CS. Costimulation of T cell receptor-triggered IL-2 production by Jurkat T cells via fibroblast growth factor receptor 1 upon its engagement by CD56. Immunol Cell Biol. 2002;80:364-9. (Block)
6. Hanna J, Mussaffi H, Steuer G, Hanna S, Deeb M, Blau H, et al. Functional aberrant expression of CCR2 receptor on chronically activated NK cells in patients with TAP-2 deficiency. Blood. 2005;106:3465-73. (FC)
7. Olsen I, Tollefsen S, Aagaard C, Reitan LJ, Bannantine JP, Andersen P, et al. Isolation of Mycobacterium avium subspecies paratuberculosis reactive CD4 T cells from intestinal biopsies of Crohn's disease patients. PLoS One. 2009;4(5):e5641. (FC)
8. Dimova T, Mihaylova A, Spassova P, Georgieva R. Superficial implantation in pigs is associated with decreased numbers and redistribution of endometrial NK-cell populations. Am J Reprod Immunol. 2008;59:359-69. (FC, Porcine Reactivity)
9. Wilschut KJ, Jaksani S, Van Den Dolder J, Haagsman HP, Roelen BA. Isolation and characterization of porcine adult muscle-derived progenitor cells. J Cell Biochem. 2008;105:1228-39. (FC, Porcine Reactivity)
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