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Mouse Anti-Chicken β2-Microglobulin-PE (F21-21)

Cat. No.:
PE Anti-Chicken β2 antibody for use in flow cytometry assays.
Size Price (USD) Quantity
0.1 mg $237.00
More Information
Clone F21-21
Isotype Mouse IgG1κ
Isotype Control Mouse IgG1-PE (15H6)
Specificity Chicken/Turkey β2-Microglobulin
Alternative Names MHC Class I, B-F
Description Like their mammalian counterparts, avian MHC Class I molecules, also known as B-F antigens, consist of a highly polymorphic α-chain noncovalently bound to the invariant β2-microglobulin subunit. MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes which are usually cytotoxic T cells. The monoclonal antibody F21-21 also reacts with turkey β2-microglobulin.
Immunogen Affinity purified chicken MHC-I molecules
Conjugate PE (R-phycoerythrin)
Buffer Formulation Phosphate buffered saline containing < 0.1% sodium azide and a stabilizer
Clonality Monoclonal
Concentration 0.1 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C; Avoid exposure to light; Do not freeze
Applications Flow Cytometry – Quality tested 4,6-10
Immunocytochemistry – Reported in literature 3
Immunoprecipitation – Reported in literature 5,6
Western Blot – Reported in literature 1,2
Purification – Reported in literature 1,4,6

RRID Number AB_2796520
Gene ID 414830 (Chicken)
100539873 (Turkey)
Gene ID Symbol B2M (Chicken)
B2M (Turkey)
Gene ID Aliases b2m-W01; b2m-W03; b2m-Z01; b2m-Z02; b2m-Z03
UniProt ID P21611 (Chicken)
P21612 (Turkey)
UniProt Name B2MG_CHICK (Chicken)
B2MG_MELGA (Turkey)

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  1. 1. Skjødt K, Welinder KG, Crone M, Verland S, Salomonsen J, Simonsen M. Isolation and characterization of chicken and turkey beta2-microglobulin. Mol Immunol. 1986;23:1301-9. (Immunogen, WB, Purification, Turkey Reactivity)
  2. 2. Walker BA, Hunt LG, Sowa AK, Skjødt K, Göbel TW, Lehner PJ, et al. The dominantly expressed class I molecule of the chicken MHC is explained by coevolution with the polymorphic peptide transporter (TAP) genes. Proc Natl Acad Sci USA. 2011;108:8396-401. (WB)
  3. 3. Adair BM, McNeilly F, McConnell CD, McNulty MS. Characterization of surface markers present on cells infected by chicken anemia virus in experimentally infected chickens. Avian Dis. 1993;37:943-50. (ICC)
  4. 4. Dunon D, Kaufman J, Salomonsen J, Skjoedt K, Vainio O, Thiery J, et al. T cell precursor migration towards β2-microglobulin is involved in thymus colonization of chicken embryos. EMBO J. 1990;9:3315-22. (Purification, FC)
  5. 5. Møller LB, Kaufman J, Verland S, Salomonsen J, Avila D, Lambris JD, et al. Variations in the cytoplasmic region account for the heterogeneity of the chicken MHC class I (B-F) molecules. Immunogenetics. 1991;34:110-20. (IP)
  6. 6. Wallny H, Avila D, Hunt LG, Powell TJ, Riegert P, Salomonsen J, et al. Peptide motifs of the single dominantly expressed class I molecule explain the striking MHC-determined response to Rous sarcoma virus in chickens. Proc Natl Acad Sci USA. 2006;103:1434-9. (FC, IP, Purification)
  7. 7. Buitenhuis AJ, Kjaer JB, Labouriau R, Juul-Madsen HR. Altered circulating levels of serotonin and immunological changes in laying hens divergently selected for feather pecking behavior. Poult Sci. 2006;85:1722-8. (FC)
  8. 8. Juul-Madsen HR, Dalgaard TS, Røntved CM, Jensen KH, Bumstead N. Immune response to a killed infectious bursal disease virus vaccine in inbred chicken lines with different major histocompatibility complex haplotypes. Poult Sci. 2006;85:986-98. (FC)
  9. 9. Dalgaard T, Boving MK, Handberg K, Jensen KH, Norup LR, Juul-Madsen HR. MHC expression on spleen lymphocyte subsets in genetically resistant and susceptible chickens infected with Marek's disease virus. Viral Immunol. 2009;22:321-7. (FC)
  10. 10. Meyerhoff RR, Ali RA, Liu K, Huang G, Koci MD. Comprehensive analysis of commercially available mouse antichicken monoclonal antibodies for cross-reactivity with peripheral blood leukocytes from commercial turkeys. Poult Sci. 2012;91:383-92. (FC, Turkey Reactivity)
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